TY - JOUR
T1 - Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19
AU - on behalf of the North American Alliance for the Study of Digestive Manifestations of Covid-19
AU - Aroniadis, Olga C.
AU - Wang, Xianling
AU - Gong, Tang
AU - Forbes, Nauzer
AU - Yang, Jeong Yun
AU - Canakis, Andrew
AU - Elmunzer, Badih Joseph
AU - Yadav, Dhiraj
AU - Aroniadis, Olga C.
AU - Elmunzer, B. Joseph
AU - Elmunzer, B. Joseph
AU - Spitzer, Rebecca L.
AU - Dixon, Rebekah E.
AU - Ordiah, Collins O.
AU - Kolb, Jennifer M.
AU - Wani, Sachin
AU - Aroniadis, Olga Olga C.
AU - Mendelsohn, Robin B.
AU - DiMaio, Christopher J.
AU - Rockey, Don C.
AU - Singal, Amit G.
AU - Deshpande, Amar R.
AU - Pawa, Swati
AU - Conwell, Darwin L.
AU - Muthusamy, Raman
AU - Tierney, William M.
AU - Alford, Teldon B.
AU - Wakefield, Lauren
AU - Nitchie, Haley
AU - Ordiah, Collins O.
AU - Spitzer, Rebecca L.
AU - Merchant, Ambreen A.
AU - Patel, Vaishali A.
AU - Willingham, Field F.
AU - Howard, Eric F.
AU - West, Mary K.
AU - Koza, Casey L.
AU - Yachimski, Patrick S.
AU - Qayed, Emad
AU - Nustas, Rosemary
AU - Zakaria, Ali
AU - Piper, Marc S.
AU - Taylor, Jason R.
AU - Jaza, Lujain
AU - Chau, Millie
AU - Lara, Luis F.
AU - Papachristou, Georgios I.
AU - Okafor, Uchechi
AU - Volk, Michael L.
AU - Mosier, Evan
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Background and Aims: The most common symptoms of Covid-19 are respiratory; however, gastrointestinal symptoms are present in up to 50% of patients. We aimed to determine characteristics associated with the development of gastrointestinal symptoms in patients with Covid-19. Methods: A case–control study of adults hospitalized for Covid-19 was conducted across a geographically diverse alliance of 36 US and Canadian medical centers. Data were manually abstracted from electronic health records and analyzed using regression analyses to determine characteristics associated with any gastrointestinal symptoms and diarrhea specifically. Results: Of 1406 patients, 540 (38%) reported at least one gastrointestinal symptom and 346 (25%) reported diarrhea. Older patients (≥ 80 years) had significantly lower rates of any gastrointestinal symptoms and diarrhea (vs. patients 18–79 years, OR 0.41, p < 0.01 and OR 0.43 p = 0.01, respectively), while those with IBS (OR 7.70, p = 0.02 and OR 6.72, p < 0.01, respectively) and on immunosuppressive therapy (OR = 1.56, p = 0.02) had higher rates of any gastrointestinal symptom and diarrhea. Patients with constitutional symptoms exhibited significantly higher rates (OR 1.91, p < 0.01), while those with pulmonary disease alone had lower rates of gastrointestinal symptoms (OR 0.23, p = 0.01). A significant interaction between constitutional symptoms and pre-existing pulmonary conditions was observed. Conclusions: Several patient- and disease-specific characteristics associate with gastrointestinal symptoms in patients with Covid-19. Knowledge of these may provide insights into associated pathophysiologic mechanisms, and help health care professionals provide targeted attention to reduce morbidity related to Covid-19.
AB - Background and Aims: The most common symptoms of Covid-19 are respiratory; however, gastrointestinal symptoms are present in up to 50% of patients. We aimed to determine characteristics associated with the development of gastrointestinal symptoms in patients with Covid-19. Methods: A case–control study of adults hospitalized for Covid-19 was conducted across a geographically diverse alliance of 36 US and Canadian medical centers. Data were manually abstracted from electronic health records and analyzed using regression analyses to determine characteristics associated with any gastrointestinal symptoms and diarrhea specifically. Results: Of 1406 patients, 540 (38%) reported at least one gastrointestinal symptom and 346 (25%) reported diarrhea. Older patients (≥ 80 years) had significantly lower rates of any gastrointestinal symptoms and diarrhea (vs. patients 18–79 years, OR 0.41, p < 0.01 and OR 0.43 p = 0.01, respectively), while those with IBS (OR 7.70, p = 0.02 and OR 6.72, p < 0.01, respectively) and on immunosuppressive therapy (OR = 1.56, p = 0.02) had higher rates of any gastrointestinal symptom and diarrhea. Patients with constitutional symptoms exhibited significantly higher rates (OR 1.91, p < 0.01), while those with pulmonary disease alone had lower rates of gastrointestinal symptoms (OR 0.23, p = 0.01). A significant interaction between constitutional symptoms and pre-existing pulmonary conditions was observed. Conclusions: Several patient- and disease-specific characteristics associate with gastrointestinal symptoms in patients with Covid-19. Knowledge of these may provide insights into associated pathophysiologic mechanisms, and help health care professionals provide targeted attention to reduce morbidity related to Covid-19.
KW - Characteristics
KW - Covid-19
KW - Gastrointestinal symptoms
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U2 - 10.1007/s10620-021-07286-7
DO - 10.1007/s10620-021-07286-7
M3 - Article
C2 - 34751837
AN - SCOPUS:85118765038
SN - 0163-2116
VL - 67
SP - 3860
EP - 3871
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 8
ER -