Factors influencing adrenal metastasis in renal cell carcinoma

Arthur I Sagalowsky, K. T. Kadesky, D. M. Ewalt, T. J. Kennedy

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

The factors predisposing to adrenal metastasis in renal cell carcinoma were reviewed in 695 cases. The overall incidence of adrenal metastasis was 4.3%. The risk of adrenal metastasis correlated with tumors that were on the left side, large and replacing the entire kidney, upper pole in location and of advanced T stage. Nevertheless, microscopic and/or contralateral adrenal metastasis was noted in patients with smaller, lower pole or mid renal tumors. Of 30 patients with adrenal metastasis 9 (30%) had clinical evidence of widespread disease. Among the patients who underwent complete surgical resection 14% had either positive lymph nodes or other nonadrenal metastases. Of the patients undergoing resection 81% died, with a mean postoperative survival of 27 months. Sustained disease-free survival was noted in 3 patients (0.43% of the entire series) whose complete pathological staging was pT1-3b, N0, M0. The need and benefit of adrenalectomy during surgery for renal cell carcinoma are extremely limited.

Original languageEnglish (US)
Pages (from-to)1181-1184
Number of pages4
JournalJournal of Urology
Volume151
Issue number5
StatePublished - 1994

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Renal Cell Carcinoma
Neoplasm Metastasis
Kidney
Adrenalectomy
Causality
Disease-Free Survival
Neoplasms
Lymph Nodes
Survival
Incidence

Keywords

  • adrenal neoplasms
  • carcinoma, renal cell
  • kidney neoplasms
  • neoplasm metastasis

ASJC Scopus subject areas

  • Urology

Cite this

Sagalowsky, A. I., Kadesky, K. T., Ewalt, D. M., & Kennedy, T. J. (1994). Factors influencing adrenal metastasis in renal cell carcinoma. Journal of Urology, 151(5), 1181-1184.

Factors influencing adrenal metastasis in renal cell carcinoma. / Sagalowsky, Arthur I; Kadesky, K. T.; Ewalt, D. M.; Kennedy, T. J.

In: Journal of Urology, Vol. 151, No. 5, 1994, p. 1181-1184.

Research output: Contribution to journalArticle

Sagalowsky, AI, Kadesky, KT, Ewalt, DM & Kennedy, TJ 1994, 'Factors influencing adrenal metastasis in renal cell carcinoma', Journal of Urology, vol. 151, no. 5, pp. 1181-1184.
Sagalowsky AI, Kadesky KT, Ewalt DM, Kennedy TJ. Factors influencing adrenal metastasis in renal cell carcinoma. Journal of Urology. 1994;151(5):1181-1184.
Sagalowsky, Arthur I ; Kadesky, K. T. ; Ewalt, D. M. ; Kennedy, T. J. / Factors influencing adrenal metastasis in renal cell carcinoma. In: Journal of Urology. 1994 ; Vol. 151, No. 5. pp. 1181-1184.
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