Factors promoting the survival and beating of intact foetal mouse hearts in organ culture

K. Wildenthal

doi:10.1016/0022-2828(70)90031-3

Factors promoting the survival and beating of intact foetal mouse hearts in organ culture

K. Wildenthal

Internal Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A method for cultivating intact foetal mouse hearts in vitro has been developed. The hearts survive and beat rhythmically and spontaneously for 3 weeks or more under appropriate cultural conditions. Prolonged function is promoted by atmospheres containing greater than 20% O₂ and by media supplemented with serum, insulin and cortisol.

Original language	English (US)
Pages (from-to)	101-104
Number of pages	4
Journal	Journal of Molecular and Cellular Cardiology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0022-2828(70)90031-3
State	Published - Mar 1970

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/0022-2828(70)90031-3

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title = "Factors promoting the survival and beating of intact foetal mouse hearts in organ culture",

abstract = "A method for cultivating intact foetal mouse hearts in vitro has been developed. The hearts survive and beat rhythmically and spontaneously for 3 weeks or more under appropriate cultural conditions. Prolonged function is promoted by atmospheres containing greater than 20% O2 and by media supplemented with serum, insulin and cortisol.",

author = "K. Wildenthal",

note = "Funding Information: The generous and invaluable help of Dame Honor B. Fell, F.R.S. in all aspects of this work is gratefully acknowledged. Figures were prepared by MIr M. Applin. The study was supported in part by a grant from the U.S. Public Health Service, and was done during the tenure of Special Fellowship No. 6 F03 HE3196{\textquoteright}7-01 from the National Heart Institute.",

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AU - Wildenthal, K.

N1 - Funding Information: The generous and invaluable help of Dame Honor B. Fell, F.R.S. in all aspects of this work is gratefully acknowledged. Figures were prepared by MIr M. Applin. The study was supported in part by a grant from the U.S. Public Health Service, and was done during the tenure of Special Fellowship No. 6 F03 HE3196’7-01 from the National Heart Institute.

PY - 1970/3

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N2 - A method for cultivating intact foetal mouse hearts in vitro has been developed. The hearts survive and beat rhythmically and spontaneously for 3 weeks or more under appropriate cultural conditions. Prolonged function is promoted by atmospheres containing greater than 20% O2 and by media supplemented with serum, insulin and cortisol.

AB - A method for cultivating intact foetal mouse hearts in vitro has been developed. The hearts survive and beat rhythmically and spontaneously for 3 weeks or more under appropriate cultural conditions. Prolonged function is promoted by atmospheres containing greater than 20% O2 and by media supplemented with serum, insulin and cortisol.

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Factors promoting the survival and beating of intact foetal mouse hearts in organ culture

Abstract

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