Faecal bile acids are natural ligands of the mouse accessory olfactory system

Wayne I. Doyle, Jordan A. Dinser, Hillary L. Cansler, Xingjian Zhang, Daniel D. Dinh, Natasha S. Browder, Ian M. Riddington, Julian P. Meeks

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The accessory olfactory system (AOS) guides behaviours that are important for survival and reproduction, but understanding of AOS function is limited by a lack of identified natural ligands. Here we report that mouse faeces are a robust source of AOS chemosignals and identify bile acids as a class of natural AOS ligands. Single-unit electrophysiological recordings from accessory olfactory bulb neurons in ex vivo preparations show that AOS neurons are strongly and selectively activated by peripheral stimulation with mouse faecal extracts. Faecal extracts contain several unconjugated bile acids that cause concentration-dependent neuronal activity in the AOS. Many AOS neurons respond selectively to bile acids that are variably excreted in male and female mouse faeces, and others respond to bile acids absent in mouse faeces. These results identify faeces as a natural source of AOS information, and suggest that bile acids may be mammalian pheromones and kairomones.

Original languageEnglish (US)
Article number11936
JournalNature Communications
Volume7
DOIs
StatePublished - Jun 21 2016

Fingerprint

accessories
Accessories
Bile Acids and Salts
mice
Feces
Ligands
feces
ligands
acids
Pheromones
Neurons
neurons
Olfactory Bulb
Information Systems
Reproduction
bulbs
information systems
stimulation
Information systems
recording

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Doyle, W. I., Dinser, J. A., Cansler, H. L., Zhang, X., Dinh, D. D., Browder, N. S., ... Meeks, J. P. (2016). Faecal bile acids are natural ligands of the mouse accessory olfactory system. Nature Communications, 7, [11936]. https://doi.org/10.1038/ncomms11936

Faecal bile acids are natural ligands of the mouse accessory olfactory system. / Doyle, Wayne I.; Dinser, Jordan A.; Cansler, Hillary L.; Zhang, Xingjian; Dinh, Daniel D.; Browder, Natasha S.; Riddington, Ian M.; Meeks, Julian P.

In: Nature Communications, Vol. 7, 11936, 21.06.2016.

Research output: Contribution to journalArticle

Doyle, WI, Dinser, JA, Cansler, HL, Zhang, X, Dinh, DD, Browder, NS, Riddington, IM & Meeks, JP 2016, 'Faecal bile acids are natural ligands of the mouse accessory olfactory system', Nature Communications, vol. 7, 11936. https://doi.org/10.1038/ncomms11936
Doyle WI, Dinser JA, Cansler HL, Zhang X, Dinh DD, Browder NS et al. Faecal bile acids are natural ligands of the mouse accessory olfactory system. Nature Communications. 2016 Jun 21;7. 11936. https://doi.org/10.1038/ncomms11936
Doyle, Wayne I. ; Dinser, Jordan A. ; Cansler, Hillary L. ; Zhang, Xingjian ; Dinh, Daniel D. ; Browder, Natasha S. ; Riddington, Ian M. ; Meeks, Julian P. / Faecal bile acids are natural ligands of the mouse accessory olfactory system. In: Nature Communications. 2016 ; Vol. 7.
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