Failure of adrenalcorticosteroids to influence the major mechanisms of hepatic cholesterogenesis

Flavio O. Nervi, John M. Dietschy

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Several lines of evidence suggest that adrenalcorticosteroids may play a role in controlling the rate at which the liver synthesizes cholesterol, yet the published data on this point are contradictory. Under conditions of carefully controlled dietary intake and cyclic lighting the effect of bilateral adrenalectomy on the alterations in hepatic sterol synthesis caused by diurnal variation in lighting, cholestyramine feeding, fasting, intravenous intestinal lipoprotein injection and stress was investigated in the rat. Adrenalectomy caused no alterations in the rate of hepatic CO2 production or of cholesterol or ketone body synthesis. Cholesterogenesis varied from 255 to 738 nmoles · g-1 · h-1, respectively, in the mid-light and mid-dark phases of the light cycle in control animals: identical variation was found in adrenalectomized animals. Cholestyramine feeding caused a 3-fold increase in hepatic Cholesterogenesis in both control and corticosterone-deficient groups. Cholesterol synthesis was markedly suppressed in control rats and in rats with adrenalectomy by fasting for 48 h and by intravenous injection of intestinal lipoproteins. Finally, stress induced a 10-fold increase in the rate of hepatic Cholesterogenesis in both the adrenaldeficient and control animals. Thus, these studies showed that adrenalectomized animals responded in an essentially normal manner to all of the major physiological maneuvers tested that are known to affect the rate of hepatic cholesterol synthesis.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume369
Issue number3
DOIs
StatePublished - Dec 17 1974

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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