Failure of Furazolidone Therapy in Shigellosis

K. C. Haltalin, J. D. Nelson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Dilution susceptibility testing of 139 Shigella isolates from patients with acute shigellosis showed that all were inhibited by concentrations of 2.5μg of furazolidone per milliliter, with the majority being inhibited by 0.625μg/ml or less. Nineteen infants and children hospitalized for severe shigellosis were treated with 8 mg/kg/day of furazolidone for five days. Persistence of positive stool cultures for more than 48 hours or relapse after initial bacteriologic response was observed in 13 patients (68%). Clinical failure occurred in eight patients (42%). There was no decrease in the numbers of Shigella per gram of feces shed during therapy compared with pretreatment quantitations. The clinical and bacteriologic results of furazolidone therapy are comparable to the natural course of illness seen in placebo-treated patients and markedly inferior to those obtained with ampicillin therapy. On the basis of these findings and a review of previous reports we conclude that furazolidone is ineffective and should not be recommended for treating shigellosis.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume123
Issue number1
DOIs
StatePublished - Jan 1972

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Failure of Furazolidone Therapy in Shigellosis'. Together they form a unique fingerprint.

Cite this