Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease

N. Pomara, E. F. Domino, H. Yoon, S. Brinkman, C. A. Tamminga, S. Gershon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of a single dose (15 g/70 kg) of lecithin (95% phosphatidylcholine) on several measures of central cholinergic activity (memory, cortisol, prolactin, pulse, blood pressure) was assessed in individuals with Alzheimer's disease. In contrast to the reported effects of physostigmine, a cholinesterase inhibitor, lecithin had no effect on these parameters, despite significant increases in plasma and erythrocyte choline.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalJournal of Clinical Psychiatry
Volume44
Issue number8 I
StatePublished - 1983

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Lecithins
Cholinergic Agents
Alzheimer Disease
Blood Pressure
Physostigmine
Cholinesterase Inhibitors
Choline
Phosphatidylcholines
Prolactin
Hydrocortisone
Erythrocytes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease. / Pomara, N.; Domino, E. F.; Yoon, H.; Brinkman, S.; Tamminga, C. A.; Gershon, S.

In: Journal of Clinical Psychiatry, Vol. 44, No. 8 I, 1983, p. 293-295.

Research output: Contribution to journalArticle

Pomara, N, Domino, EF, Yoon, H, Brinkman, S, Tamminga, CA & Gershon, S 1983, 'Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease', Journal of Clinical Psychiatry, vol. 44, no. 8 I, pp. 293-295.
Pomara, N. ; Domino, E. F. ; Yoon, H. ; Brinkman, S. ; Tamminga, C. A. ; Gershon, S. / Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease. In: Journal of Clinical Psychiatry. 1983 ; Vol. 44, No. 8 I. pp. 293-295.
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