Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease

N. Pomara, E. F. Domino, H. Yoon, S. Brinkman, C. A. Tamminga, S. Gershon

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Abstract

The effect of a single dose (15 g/70 kg) of lecithin (95% phosphatidylcholine) on several measures of central cholinergic activity (memory, cortisol, prolactin, pulse, blood pressure) was assessed in individuals with Alzheimer's disease. In contrast to the reported effects of physostigmine, a cholinesterase inhibitor, lecithin had no effect on these parameters, despite significant increases in plasma and erythrocyte choline.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalJournal of Clinical Psychiatry
Volume44
Issue number8 I
StatePublished - Oct 6 1983

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ASJC Scopus subject areas

  • Psychiatry and Mental health

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