@article{df6d895f461a46048fa0914df1b4b18a,
title = "Familial aggregation and co-aggregation of essential tremor and Parkinson's disease",
abstract = "Background: Current data suggest that the 2 common tremor disorders, essential tremor (ET) and Parkinson's disease (PD), may be associated with one another. Familial aggregation studies allow one to further explore their relatedness. Methods: Probands with ET (n = 110), PD (n = 130) or both ET and PD (n = 27) and control probands (n = 177) reported whether they had relatives with these diseases or with nonspecific tremor. Results: A greater proportion of ET probands than control probands reported relatives with ET (30.0 vs. 2.8%, p < 0.001), non-specific tremor (38.2 vs. 13.6%, p < 0.001) and both ET and PD in different relatives (6.4 vs. 0.6%, p = 0.004). A greater proportion of PD probands than control probands reported relatives with PD (20.0 vs. 8.5%, p = 0.003), ET (11.5 vs. 2.8%, p = 0.002) and both ET and PD in different relatives (6.9 vs. 0.6%, p = 0.002). Conclusions: This study provides evidence for the aggregation of ET in ET families and PD in PD families, and the familial co-aggregation of ET and PD.",
keywords = "Essential tremor, Familial aggregation, Genetic epidemiology, Neurodegeneration, Parkinson's disease",
author = "Louis, {Elan D.} and Lorraine Clark and Ruth Ottman",
note = "Funding Information: Dr. E.D. Louis has received research support from the National Institutes of Health: NINDS R01 NS042859 (principal investigator), NINDS R01 NS39422 (principal investigator), NINDS R01 NS086736 (principal investigator), NINDS R01 NS073872 (principal investigator), NINDS R01 NS085136 (principal investigator) and NINDS R01 NS088257 (principal investigator). Dr. L. Clark has received research support from the National Institutes of Health: NINDS R21 NS050487 (principal investigator), R01 NS060113 (principal investigator), R01 NS0738072 (principal investigator), P50 AG008702 (co-investigator), P50 NS038370 (co-investigator), the Parkinson?s Disease Foundation (principal investigator) and The Michael J. Fox Foundation (co-investigator). Dr. R. Ottman has received research support from the National Institutes of Health through U01 NS077276 (multiple-PI), R01 NS078419 (principal investigator), P50 HG007257 (co-investigator), R01 NS073872 (coinvestigator) and R01 AG041797 (co-investigator). Funding Information: Dr. E.D. Louis has received research support from the National Institutes of Health: NINDS R01 NS042859 (principal investigator), NINDS R01 NS39422 (principal investigator), NINDS R01 NS086736 (principal investigator), NINDS R01 NS073872 (principal investigator), NINDS R01 NS085136 (principal investigator) and NINDS R01 NS088257 (principal investigator). Dr. L. Clark has received research support from the National Institutes of Health: NINDS R21 NS050487 (principal investigator), R01 NS060113 (principal investigator), R01 NS0738072 (principal investigator), P50 AG008702 (co-investigator), P50 NS038370 (co-investigator), the Parkinson{\textquoteright}s Disease Foundation (principal investigator) and The Michael J. Fox Foundation (co-investigator). Dr. R. Ottman has received research support from the National Institutes of Health through U01 NS077276 (multiple-PI), R01 NS078419 (principal investigator), P50 HG007257 (co-investigator), R01 NS073872 (coinvestigator) and R01 AG041797 (co-investigator). Publisher Copyright: {\textcopyright} 2016 S. Karger AG, Basel.",
year = "2016",
month = jan,
day = "1",
doi = "10.1159/000442021",
language = "English (US)",
volume = "46",
pages = "31--36",
journal = "Neuroepidemiology",
issn = "0251-5350",
publisher = "S. Karger AG",
number = "1",
}