Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

Sampath Prahalad, Courtney E. McCracken, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster Stevens, Larry B. Vogler, Carl D. Langefeld, Susan D. Thompson, L. Abramson, E. Anderson, M. Andrew, N. Battle, M. Becker, H. Benham, T. Beukelman, J. Birmingham, P. Blier, A. Brown, H. Brunner, A. Cabrera & 107 others D. Canter, D. Carlton, B. Caruso, L. Ceracchio, E. Chalom, J. Chang, P. Charpentier, K. Clark, J. Dean, F. Dedeoglu, B. Feldman, P. Ferguson, M. Fox, K. Francis, M. Gervasini, D. Goldsmith, G. Gorton, B. Gottlieb, T. Graham, T. Griffin, H. Grosbein, S. Guppy, H. Haftel, D. Helfrich, G. Higgins, A. Hillard, J. R. Hollister, J. Hsu, A. Hudgins, C. Hung, A. Huttenlocher, N. Ilowite, A. Imlay, L. Imundo, C. J. Inman, J. Jaqith, R. Jerath, L. Jung, P. Kahn, A. Kapedani, D. Kingsbury, K. Klein, M. Klein-Gitelman, A. Kunkel, S. Lapidus, S. Layburn, T. Lehman, C. Lindsley, M. Macgregor-Hannah, M. Malloy, C. Mawhorter, D. McCurdy, K. Mims, N. Moorthy, D. Morus, E. Muscal, M. Natter, J. Olson, K. O'Neil, K. Onel, M. Orlando, J. Palmquist, M. Phillips, L. Ponder, S. Prahalad, M. Punaro, D. Puplava, S. Quinn, A. Quintero, C. Rabinovich, A. Reed, C. Reed, S. Ringold, M. Riordan, S. Roberson, A. Robinson, J. Rossette, D. Rothman, D. Russo, N. Ruth, K. Schikler, A. Sestak, B. Shaham, Y. Sherman, M. Simmons, N. Singer, S. Spalding, H. Stapp, R. Syed, E. Thomas, K. Torok, D. Trejo, J. Tress, W. Upton, R. Vehe, E. von Scheven, L. Walters, J. Weiss, P. Weiss, N. Welnick, A. White, J. Woo, J. Wootton, A. Yalcindag, C. Zapp, L. Zemel, A. Zhu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5%) was less compared to subjects with JIA (31.8%, p <0.001) or SLE (31.9%; p <0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13%) compared to cSLE (9.2%, p = 0.007) or JDM (4.3%, p

Original languageEnglish (US)
Article number14
JournalPediatric Rheumatology
Volume14
Issue number1
DOIs
StatePublished - Mar 10 2016

Fingerprint

Juvenile Arthritis
Rheumatology
Autoimmunity
Arthritis
Registries
Systemic Lupus Erythematosus
Research
Genetic Predisposition to Disease
Rheumatic Diseases
Autoimmune Diseases
Juvenile dermatomyositis
Pediatrics
Phenotype

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

Prahalad, S., McCracken, C. E., Ponder, L. A., Angeles-Han, S. T., Rouster Stevens, K. A., Vogler, L. B., ... Zhu, A. (2016). Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry. Pediatric Rheumatology, 14(1), [14]. https://doi.org/10.1186/s12969-016-0075-7

Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry. / Prahalad, Sampath; McCracken, Courtney E.; Ponder, Lori A.; Angeles-Han, Sheila T.; Rouster Stevens, Kelly A.; Vogler, Larry B.; Langefeld, Carl D.; Thompson, Susan D.; Abramson, L.; Anderson, E.; Andrew, M.; Battle, N.; Becker, M.; Benham, H.; Beukelman, T.; Birmingham, J.; Blier, P.; Brown, A.; Brunner, H.; Cabrera, A.; Canter, D.; Carlton, D.; Caruso, B.; Ceracchio, L.; Chalom, E.; Chang, J.; Charpentier, P.; Clark, K.; Dean, J.; Dedeoglu, F.; Feldman, B.; Ferguson, P.; Fox, M.; Francis, K.; Gervasini, M.; Goldsmith, D.; Gorton, G.; Gottlieb, B.; Graham, T.; Griffin, T.; Grosbein, H.; Guppy, S.; Haftel, H.; Helfrich, D.; Higgins, G.; Hillard, A.; Hollister, J. R.; Hsu, J.; Hudgins, A.; Hung, C.; Huttenlocher, A.; Ilowite, N.; Imlay, A.; Imundo, L.; Inman, C. J.; Jaqith, J.; Jerath, R.; Jung, L.; Kahn, P.; Kapedani, A.; Kingsbury, D.; Klein, K.; Klein-Gitelman, M.; Kunkel, A.; Lapidus, S.; Layburn, S.; Lehman, T.; Lindsley, C.; Macgregor-Hannah, M.; Malloy, M.; Mawhorter, C.; McCurdy, D.; Mims, K.; Moorthy, N.; Morus, D.; Muscal, E.; Natter, M.; Olson, J.; O'Neil, K.; Onel, K.; Orlando, M.; Palmquist, J.; Phillips, M.; Ponder, L.; Prahalad, S.; Punaro, M.; Puplava, D.; Quinn, S.; Quintero, A.; Rabinovich, C.; Reed, A.; Reed, C.; Ringold, S.; Riordan, M.; Roberson, S.; Robinson, A.; Rossette, J.; Rothman, D.; Russo, D.; Ruth, N.; Schikler, K.; Sestak, A.; Shaham, B.; Sherman, Y.; Simmons, M.; Singer, N.; Spalding, S.; Stapp, H.; Syed, R.; Thomas, E.; Torok, K.; Trejo, D.; Tress, J.; Upton, W.; Vehe, R.; von Scheven, E.; Walters, L.; Weiss, J.; Weiss, P.; Welnick, N.; White, A.; Woo, J.; Wootton, J.; Yalcindag, A.; Zapp, C.; Zemel, L.; Zhu, A.

In: Pediatric Rheumatology, Vol. 14, No. 1, 14, 10.03.2016.

Research output: Contribution to journalArticle

Prahalad, S, McCracken, CE, Ponder, LA, Angeles-Han, ST, Rouster Stevens, KA, Vogler, LB, Langefeld, CD, Thompson, SD, Abramson, L, Anderson, E, Andrew, M, Battle, N, Becker, M, Benham, H, Beukelman, T, Birmingham, J, Blier, P, Brown, A, Brunner, H, Cabrera, A, Canter, D, Carlton, D, Caruso, B, Ceracchio, L, Chalom, E, Chang, J, Charpentier, P, Clark, K, Dean, J, Dedeoglu, F, Feldman, B, Ferguson, P, Fox, M, Francis, K, Gervasini, M, Goldsmith, D, Gorton, G, Gottlieb, B, Graham, T, Griffin, T, Grosbein, H, Guppy, S, Haftel, H, Helfrich, D, Higgins, G, Hillard, A, Hollister, JR, Hsu, J, Hudgins, A, Hung, C, Huttenlocher, A, Ilowite, N, Imlay, A, Imundo, L, Inman, CJ, Jaqith, J, Jerath, R, Jung, L, Kahn, P, Kapedani, A, Kingsbury, D, Klein, K, Klein-Gitelman, M, Kunkel, A, Lapidus, S, Layburn, S, Lehman, T, Lindsley, C, Macgregor-Hannah, M, Malloy, M, Mawhorter, C, McCurdy, D, Mims, K, Moorthy, N, Morus, D, Muscal, E, Natter, M, Olson, J, O'Neil, K, Onel, K, Orlando, M, Palmquist, J, Phillips, M, Ponder, L, Prahalad, S, Punaro, M, Puplava, D, Quinn, S, Quintero, A, Rabinovich, C, Reed, A, Reed, C, Ringold, S, Riordan, M, Roberson, S, Robinson, A, Rossette, J, Rothman, D, Russo, D, Ruth, N, Schikler, K, Sestak, A, Shaham, B, Sherman, Y, Simmons, M, Singer, N, Spalding, S, Stapp, H, Syed, R, Thomas, E, Torok, K, Trejo, D, Tress, J, Upton, W, Vehe, R, von Scheven, E, Walters, L, Weiss, J, Weiss, P, Welnick, N, White, A, Woo, J, Wootton, J, Yalcindag, A, Zapp, C, Zemel, L & Zhu, A 2016, 'Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry', Pediatric Rheumatology, vol. 14, no. 1, 14. https://doi.org/10.1186/s12969-016-0075-7
Prahalad S, McCracken CE, Ponder LA, Angeles-Han ST, Rouster Stevens KA, Vogler LB et al. Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry. Pediatric Rheumatology. 2016 Mar 10;14(1). 14. https://doi.org/10.1186/s12969-016-0075-7
Prahalad, Sampath ; McCracken, Courtney E. ; Ponder, Lori A. ; Angeles-Han, Sheila T. ; Rouster Stevens, Kelly A. ; Vogler, Larry B. ; Langefeld, Carl D. ; Thompson, Susan D. ; Abramson, L. ; Anderson, E. ; Andrew, M. ; Battle, N. ; Becker, M. ; Benham, H. ; Beukelman, T. ; Birmingham, J. ; Blier, P. ; Brown, A. ; Brunner, H. ; Cabrera, A. ; Canter, D. ; Carlton, D. ; Caruso, B. ; Ceracchio, L. ; Chalom, E. ; Chang, J. ; Charpentier, P. ; Clark, K. ; Dean, J. ; Dedeoglu, F. ; Feldman, B. ; Ferguson, P. ; Fox, M. ; Francis, K. ; Gervasini, M. ; Goldsmith, D. ; Gorton, G. ; Gottlieb, B. ; Graham, T. ; Griffin, T. ; Grosbein, H. ; Guppy, S. ; Haftel, H. ; Helfrich, D. ; Higgins, G. ; Hillard, A. ; Hollister, J. R. ; Hsu, J. ; Hudgins, A. ; Hung, C. ; Huttenlocher, A. ; Ilowite, N. ; Imlay, A. ; Imundo, L. ; Inman, C. J. ; Jaqith, J. ; Jerath, R. ; Jung, L. ; Kahn, P. ; Kapedani, A. ; Kingsbury, D. ; Klein, K. ; Klein-Gitelman, M. ; Kunkel, A. ; Lapidus, S. ; Layburn, S. ; Lehman, T. ; Lindsley, C. ; Macgregor-Hannah, M. ; Malloy, M. ; Mawhorter, C. ; McCurdy, D. ; Mims, K. ; Moorthy, N. ; Morus, D. ; Muscal, E. ; Natter, M. ; Olson, J. ; O'Neil, K. ; Onel, K. ; Orlando, M. ; Palmquist, J. ; Phillips, M. ; Ponder, L. ; Prahalad, S. ; Punaro, M. ; Puplava, D. ; Quinn, S. ; Quintero, A. ; Rabinovich, C. ; Reed, A. ; Reed, C. ; Ringold, S. ; Riordan, M. ; Roberson, S. ; Robinson, A. ; Rossette, J. ; Rothman, D. ; Russo, D. ; Ruth, N. ; Schikler, K. ; Sestak, A. ; Shaham, B. ; Sherman, Y. ; Simmons, M. ; Singer, N. ; Spalding, S. ; Stapp, H. ; Syed, R. ; Thomas, E. ; Torok, K. ; Trejo, D. ; Tress, J. ; Upton, W. ; Vehe, R. ; von Scheven, E. ; Walters, L. ; Weiss, J. ; Weiss, P. ; Welnick, N. ; White, A. ; Woo, J. ; Wootton, J. ; Yalcindag, A. ; Zapp, C. ; Zemel, L. ; Zhu, A. / Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry. In: Pediatric Rheumatology. 2016 ; Vol. 14, No. 1.
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title = "Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry",
abstract = "Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5{\%}) was less compared to subjects with JIA (31.8{\%}, p <0.001) or SLE (31.9{\%}; p <0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13{\%}) compared to cSLE (9.2{\%}, p = 0.007) or JDM (4.3{\%}, p",
author = "Sampath Prahalad and McCracken, {Courtney E.} and Ponder, {Lori A.} and Angeles-Han, {Sheila T.} and {Rouster Stevens}, {Kelly A.} and Vogler, {Larry B.} and Langefeld, {Carl D.} and Thompson, {Susan D.} and L. Abramson and E. Anderson and M. Andrew and N. Battle and M. Becker and H. Benham and T. Beukelman and J. Birmingham and P. Blier and A. Brown and H. Brunner and A. Cabrera and D. Canter and D. Carlton and B. Caruso and L. Ceracchio and E. Chalom and J. Chang and P. Charpentier and K. Clark and J. Dean and F. Dedeoglu and B. Feldman and P. Ferguson and M. Fox and K. Francis and M. Gervasini and D. Goldsmith and G. Gorton and B. Gottlieb and T. Graham and T. Griffin and H. Grosbein and S. Guppy and H. Haftel and D. Helfrich and G. Higgins and A. Hillard and Hollister, {J. R.} and J. Hsu and A. Hudgins and C. Hung and A. Huttenlocher and N. Ilowite and A. Imlay and L. Imundo and Inman, {C. J.} and J. Jaqith and R. Jerath and L. Jung and P. Kahn and A. Kapedani and D. Kingsbury and K. Klein and M. Klein-Gitelman and A. Kunkel and S. Lapidus and S. Layburn and T. Lehman and C. Lindsley and M. Macgregor-Hannah and M. Malloy and C. Mawhorter and D. McCurdy and K. Mims and N. Moorthy and D. Morus and E. Muscal and M. Natter and J. Olson and K. O'Neil and K. Onel and M. Orlando and J. Palmquist and M. Phillips and L. Ponder and S. Prahalad and M. Punaro and D. Puplava and S. Quinn and A. Quintero and C. Rabinovich and A. Reed and C. Reed and S. Ringold and M. Riordan and S. Roberson and A. Robinson and J. Rossette and D. Rothman and D. Russo and N. Ruth and K. Schikler and A. Sestak and B. Shaham and Y. Sherman and M. Simmons and N. Singer and S. Spalding and H. Stapp and R. Syed and E. Thomas and K. Torok and D. Trejo and J. Tress and W. Upton and R. Vehe and {von Scheven}, E. and L. Walters and J. Weiss and P. Weiss and N. Welnick and A. White and J. Woo and J. Wootton and A. Yalcindag and C. Zapp and L. Zemel and A. Zhu",
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TY - JOUR

T1 - Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

AU - Prahalad, Sampath

AU - McCracken, Courtney E.

AU - Ponder, Lori A.

AU - Angeles-Han, Sheila T.

AU - Rouster Stevens, Kelly A.

AU - Vogler, Larry B.

AU - Langefeld, Carl D.

AU - Thompson, Susan D.

AU - Abramson, L.

AU - Anderson, E.

AU - Andrew, M.

AU - Battle, N.

AU - Becker, M.

AU - Benham, H.

AU - Beukelman, T.

AU - Birmingham, J.

AU - Blier, P.

AU - Brown, A.

AU - Brunner, H.

AU - Cabrera, A.

AU - Canter, D.

AU - Carlton, D.

AU - Caruso, B.

AU - Ceracchio, L.

AU - Chalom, E.

AU - Chang, J.

AU - Charpentier, P.

AU - Clark, K.

AU - Dean, J.

AU - Dedeoglu, F.

AU - Feldman, B.

AU - Ferguson, P.

AU - Fox, M.

AU - Francis, K.

AU - Gervasini, M.

AU - Goldsmith, D.

AU - Gorton, G.

AU - Gottlieb, B.

AU - Graham, T.

AU - Griffin, T.

AU - Grosbein, H.

AU - Guppy, S.

AU - Haftel, H.

AU - Helfrich, D.

AU - Higgins, G.

AU - Hillard, A.

AU - Hollister, J. R.

AU - Hsu, J.

AU - Hudgins, A.

AU - Hung, C.

AU - Huttenlocher, A.

AU - Ilowite, N.

AU - Imlay, A.

AU - Imundo, L.

AU - Inman, C. J.

AU - Jaqith, J.

AU - Jerath, R.

AU - Jung, L.

AU - Kahn, P.

AU - Kapedani, A.

AU - Kingsbury, D.

AU - Klein, K.

AU - Klein-Gitelman, M.

AU - Kunkel, A.

AU - Lapidus, S.

AU - Layburn, S.

AU - Lehman, T.

AU - Lindsley, C.

AU - Macgregor-Hannah, M.

AU - Malloy, M.

AU - Mawhorter, C.

AU - McCurdy, D.

AU - Mims, K.

AU - Moorthy, N.

AU - Morus, D.

AU - Muscal, E.

AU - Natter, M.

AU - Olson, J.

AU - O'Neil, K.

AU - Onel, K.

AU - Orlando, M.

AU - Palmquist, J.

AU - Phillips, M.

AU - Ponder, L.

AU - Prahalad, S.

AU - Punaro, M.

AU - Puplava, D.

AU - Quinn, S.

AU - Quintero, A.

AU - Rabinovich, C.

AU - Reed, A.

AU - Reed, C.

AU - Ringold, S.

AU - Riordan, M.

AU - Roberson, S.

AU - Robinson, A.

AU - Rossette, J.

AU - Rothman, D.

AU - Russo, D.

AU - Ruth, N.

AU - Schikler, K.

AU - Sestak, A.

AU - Shaham, B.

AU - Sherman, Y.

AU - Simmons, M.

AU - Singer, N.

AU - Spalding, S.

AU - Stapp, H.

AU - Syed, R.

AU - Thomas, E.

AU - Torok, K.

AU - Trejo, D.

AU - Tress, J.

AU - Upton, W.

AU - Vehe, R.

AU - von Scheven, E.

AU - Walters, L.

AU - Weiss, J.

AU - Weiss, P.

AU - Welnick, N.

AU - White, A.

AU - Woo, J.

AU - Wootton, J.

AU - Yalcindag, A.

AU - Zapp, C.

AU - Zemel, L.

AU - Zhu, A.

PY - 2016/3/10

Y1 - 2016/3/10

N2 - Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5%) was less compared to subjects with JIA (31.8%, p <0.001) or SLE (31.9%; p <0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13%) compared to cSLE (9.2%, p = 0.007) or JDM (4.3%, p

AB - Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5%) was less compared to subjects with JIA (31.8%, p <0.001) or SLE (31.9%; p <0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13%) compared to cSLE (9.2%, p = 0.007) or JDM (4.3%, p

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U2 - 10.1186/s12969-016-0075-7

DO - 10.1186/s12969-016-0075-7

M3 - Article

VL - 14

JO - Pediatric Rheumatology

JF - Pediatric Rheumatology

SN - 1546-0096

IS - 1

M1 - 14

ER -