Family history of cancer in children and adolescents with germ cell tumours: A report from the Children's Oncology Group

Jenny N. Poynter, Michaela Richardson, Michelle Roesler, Mark Krailo, James F. Amatruda, A. Lindsay Frazier

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background:Studies of family history of cancer in paediatric germ cell tumours (GCTs) are few, and none has had sufficient sample size to specifically evaluate family history of GCT.Methods:We utilised family history data from a paediatric GCT study to calculate standardised incidence ratios (SIR) for GCT and other cancers using age- and sex-specific incidence rates from the SEER Program.Results:This analysis included 7998 relatives of paediatric GCT probands. We observed a higher number of GCT cases than expected in male and female relatives of probands (SIR=2.38, 95% CI 1.25, 3.51 for males; SIR=14.3, 95% CI 0.29, 28.4 for females). Further, we observed a particularly strong SIR for relatives of probands with intracranial GCT (SIR=8.07, 95% CI 3.51, 12.6). The SIR for relatives of probands with ovarian GCT was also elevated but did not reach statistical significance (SIR 4.35, 95% CI 0-9.27). Other notable associations include elevated SIRs for melanoma in male relatives and reduced SIRs for lymphatic/haematologic malignancies in male and female relatives.Conclusions:These results support the hypothesis that familial aggregation of GCT occurs in males and females.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalBritish Journal of Cancer
Volume118
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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Keywords

  • epidemiology
  • germ cell tumour
  • intracranial
  • ovary
  • paediatric cancer
  • testis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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