Family history of diabetes impacts on interactions between minimal model estimates of insulin sensitivity and glucose effectiveness

X. Lopez, C. Bouché, E. Tatro, Alispn B. Goldfine

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Aims/hypothesis: Insulin resistance and glucose effectiveness (S G) are major determinants of glucose tolerance and independently predict the development of type 2 diabetes in individuals with a family history of disease. We examined the inter-relationship between insulin sensitivity (SI) and SG in offspring of two parents with type 2 diabetes and in individuals with no family history of diabetes. Methods: Fifty non-diabetic individuals, including 26 offspring of two type 2 diabetic parents (family history, FH+) and 24 with no family history of diabetes (FH-) similar in gender, age, ethnicity and body mass index (BMI) were studied. Each subject underwent a 100-g oral glucose tolerance test (OGTT) and insulin modified frequently sampled intravenous glucose tolerance, analysed using the Bergman's minimal model (MINMOD). Results: Thirteen subjects of the FH+ group and nine ofthe FH-group had impaired glucose tolerance (IGT). S I and S G were independent variables in the FH+ group, while they correlated highly with each other in the FH-group (r = 0.69, p = 0.0002). The relationship between SI and SG persisted when analysing the IGT and normal glucose tolerance subgroups separately, demonstrating that these associations were not because of differences in glycaemia. Consistently, SG strongly correlated with additional measures of insulin resistance only in the FH-group, including fasting insulin (r = 0.56, p = 0.004), homeostasis model assessment of insulin resistance (r = 0.57 p = 0.003) and BMI (r = 0.66, p = 0.0004). Conclusions: These results demonstrate that familial factors impart important physiological differences in the inter-relationship between insulin-dependent and insulin-independent glucose disposal, which may be important in modulating risk for development of disease.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalDiabetes, Obesity and Metabolism
Volume11
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Family history
  • Glucose effectiveness
  • Impaired glucose tolerance
  • Insulin sensitivity
  • Minimal model
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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