Fas deficiency exacerbates cerulein-induced pancreatitis

D. Rohan Jeyarajah, M. Kielar, S. T. Gokaslan, G. Lindberg, C. Y. Lu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Acute pancreatitis results in many deaths each year. Our understanding of the pathophysiology is limited. To better understand the impact of apoptosis versus necrosis, we compared cerulein-induced pancreatitis in Fas-deficient (MRL lpr/lpr) versus Fas-sufficient (MRL +/+) mice. Average amylase values in Fas-deficient mice were substantially greater than in the Fas-sufficient mouse. Histology graded on edema, inflammation, vacuolization, and necrosis showed greater injury in the Fas-deficient mouse. This finding suggests that the Fas pathway is important in controlling cerulein-induced pancreatitis.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalJournal of Investigative Surgery
Volume16
Issue number6
DOIs
StatePublished - Jan 1 2003

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Keywords

  • Apoptosis
  • FAS
  • Pancreatitis

ASJC Scopus subject areas

  • Surgery

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