Abstract
Acute pancreatitis results in many deaths each year. Our understanding of the pathophysiology is limited. To better understand the impact of apoptosis versus necrosis, we compared cerulein-induced pancreatitis in Fas-deficient (MRL lpr/lpr) versus Fas-sufficient (MRL +/+) mice. Average amylase values in Fas-deficient mice were substantially greater than in the Fas-sufficient mouse. Histology graded on edema, inflammation, vacuolization, and necrosis showed greater injury in the Fas-deficient mouse. This finding suggests that the Fas pathway is important in controlling cerulein-induced pancreatitis.
Original language | English (US) |
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Pages (from-to) | 325-333 |
Number of pages | 9 |
Journal | Journal of Investigative Surgery |
Volume | 16 |
Issue number | 6 |
DOIs | |
State | Published - 2003 |
Keywords
- Apoptosis
- FAS
- Pancreatitis
ASJC Scopus subject areas
- Surgery