Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 tesla

Robert L. Greenman; Leon Axel; Victor A. Ferrari; Robert E. Lenkinski

doi:10.1002/jmri.10081

Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 tesla

Robert L. Greenman, Leon Axel, Victor A. Ferrari, Robert E. Lenkinski

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Purpose: To investigate the use of a three-dimensional rapid acquisition with relaxation enhancement (RARE) pulse sequence for direct acquisition of phosphocreatine (PCr) images of the human myocardium. Materials and Methods: A short elliptical birdcage radio-frequency (RF) body coil was constructed to produce a uniform flip angle throughout the chest cavity. In vivo images using a spectrally-selective RARE sequence with a spatial resolution of 1.2 cm × 1.2 cm × 2.5 cm (4 cm³) were acquired in nine minutes and 40 seconds. Results: Scans of phantoms demonstrated excellent spectral selectivity. The signal-to-noise ratio in the myocardium ranged from 12.6 in the anterior wall to 5.3 in the mid septum. Conclusion: This study demonstrates that PCr data can be acquired using a three-dimensional RARE sequence with greater spatial and temporal resolution than spectroscopic techniques.

Original language	English (US)
Pages (from-to)	467-472
Number of pages	6
Journal	Journal of Magnetic Resonance Imaging
Volume	15
Issue number	4
DOIs	https://doi.org/10.1002/jmri.10081
State	Published - 2002

Keywords

Cardiac imaging
Metabolic imaging
Phosphocreatine imaging
RARE
Spectroscopic imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/jmri.10081

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title = "Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 tesla",

abstract = "Purpose: To investigate the use of a three-dimensional rapid acquisition with relaxation enhancement (RARE) pulse sequence for direct acquisition of phosphocreatine (PCr) images of the human myocardium. Materials and Methods: A short elliptical birdcage radio-frequency (RF) body coil was constructed to produce a uniform flip angle throughout the chest cavity. In vivo images using a spectrally-selective RARE sequence with a spatial resolution of 1.2 cm × 1.2 cm × 2.5 cm (4 cm3) were acquired in nine minutes and 40 seconds. Results: Scans of phantoms demonstrated excellent spectral selectivity. The signal-to-noise ratio in the myocardium ranged from 12.6 in the anterior wall to 5.3 in the mid septum. Conclusion: This study demonstrates that PCr data can be acquired using a three-dimensional RARE sequence with greater spatial and temporal resolution than spectroscopic techniques.",

keywords = "Cardiac imaging, Metabolic imaging, Phosphocreatine imaging, RARE, Spectroscopic imaging",

author = "Greenman, {Robert L.} and Leon Axel and Ferrari, {Victor A.} and Lenkinski, {Robert E.}",

year = "2002",

doi = "10.1002/jmri.10081",

language = "English (US)",

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pages = "467--472",

journal = "Journal of Magnetic Resonance Imaging",

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publisher = "John Wiley and Sons Inc.",

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T1 - Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 tesla

AU - Greenman, Robert L.

AU - Axel, Leon

AU - Ferrari, Victor A.

AU - Lenkinski, Robert E.

PY - 2002

Y1 - 2002

N2 - Purpose: To investigate the use of a three-dimensional rapid acquisition with relaxation enhancement (RARE) pulse sequence for direct acquisition of phosphocreatine (PCr) images of the human myocardium. Materials and Methods: A short elliptical birdcage radio-frequency (RF) body coil was constructed to produce a uniform flip angle throughout the chest cavity. In vivo images using a spectrally-selective RARE sequence with a spatial resolution of 1.2 cm × 1.2 cm × 2.5 cm (4 cm3) were acquired in nine minutes and 40 seconds. Results: Scans of phantoms demonstrated excellent spectral selectivity. The signal-to-noise ratio in the myocardium ranged from 12.6 in the anterior wall to 5.3 in the mid septum. Conclusion: This study demonstrates that PCr data can be acquired using a three-dimensional RARE sequence with greater spatial and temporal resolution than spectroscopic techniques.

AB - Purpose: To investigate the use of a three-dimensional rapid acquisition with relaxation enhancement (RARE) pulse sequence for direct acquisition of phosphocreatine (PCr) images of the human myocardium. Materials and Methods: A short elliptical birdcage radio-frequency (RF) body coil was constructed to produce a uniform flip angle throughout the chest cavity. In vivo images using a spectrally-selective RARE sequence with a spatial resolution of 1.2 cm × 1.2 cm × 2.5 cm (4 cm3) were acquired in nine minutes and 40 seconds. Results: Scans of phantoms demonstrated excellent spectral selectivity. The signal-to-noise ratio in the myocardium ranged from 12.6 in the anterior wall to 5.3 in the mid septum. Conclusion: This study demonstrates that PCr data can be acquired using a three-dimensional RARE sequence with greater spatial and temporal resolution than spectroscopic techniques.

KW - Cardiac imaging

KW - Metabolic imaging

KW - Phosphocreatine imaging

KW - RARE

KW - Spectroscopic imaging

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Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 tesla

Abstract

Keywords

ASJC Scopus subject areas

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