Fasting and postprandial plasma glucagon and glucagon-like immunoreactivity are normal in obese Pima Indians

B. Vasquez, M. Nagulesparan, Roger H Unger

Research output: Contribution to journalArticle

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Abstract

Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21 - 49 kg/m2) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p < 0.0001) and postprandial (r = 0.45, p < 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI > 35, n = 16) and nonobese (BMI < 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population.

Original languageEnglish (US)
Pages (from-to)218-220
Number of pages3
JournalHormone and Metabolic Research
Volume15
Issue number5
StatePublished - 1983

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Potassium Iodide
Peptide Hormones
Glucagon
Meals
Fasting
Hormones
Insulin
Plasmas
Glucose
Body Mass Index
Eating
Body Weight
Population
glucagon-like-immunoreactivity

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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Fasting and postprandial plasma glucagon and glucagon-like immunoreactivity are normal in obese Pima Indians. / Vasquez, B.; Nagulesparan, M.; Unger, Roger H.

In: Hormone and Metabolic Research, Vol. 15, No. 5, 1983, p. 218-220.

Research output: Contribution to journalArticle

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N2 - Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21 - 49 kg/m2) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p < 0.0001) and postprandial (r = 0.45, p < 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI > 35, n = 16) and nonobese (BMI < 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population.

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