TY - JOUR
T1 - Fat flies expanded the hippo pathway
T2 - a matter of size control.
AU - Yin, Feng
AU - Pan, Duojia
PY - 2007/4/21
Y1 - 2007/4/21
N2 - By simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.
AB - By simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.
UR - http://www.scopus.com/inward/record.url?scp=34250012663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250012663&partnerID=8YFLogxK
U2 - 10.1126/stke.3802007pe12
DO - 10.1126/stke.3802007pe12
M3 - Article
C2 - 17406009
AN - SCOPUS:34250012663
SN - 1937-9145
VL - 2007
SP - pe12
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 380
ER -