Fat imaging via magnetic resonance imaging (MRI) in young children (ages 1-4 years) without sedation

Grace E. Shearrer, Benjamin T. House, Michelle C. Gallas, Jeffrey J. Luci, Jaimie N. Davis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: This pilot study developed techniques to perform Magnetic Resonance Imaging (MRI) of specific fat deposition in 18 children (age 18 months to 4 years). Methods: The children engaged in a series of practice tests to become acclimated to the scanner noises, reduce claustrophobia, and rehearse holding still for a set time. The practice tests assessed if the child could remain still for two minutes while watching a video, first while lying on a blanket, second, on the blanket with headphones, and third, in the mock scanner. The children who passed the three practice tests were then scanned with a 3T Siemens Skyra magnet. Abdominal fat distribution (region of interest (ROI) from the top of the ileac crest to the bottom of the ribcage) volume was measured using 2-point DIXON technique. This region was chosen to give an indication of the body composition around the liver. Results: Twelve out of eighteen participants successfully completed the actual MRI scan. Chisquared test showed no significant difference between male and female pass-fail rates. The median age of completed scans was 36 months, whereas the median age for children unable to complete a scan was 28 months. The average total trunk fat was 240.9±85.2mL and the average total VAT was 37.7±25.9mLand liver fat was not quantifiable due to physiological motion. Several strategies (modeling, videos, and incentives) were identified to improve pediatric imaging in different age ranges. Conclusion: Using an age-specific and tailored protocol, we were able to successfully use MRI for fat imaging in a majority of young children. Development of such protocols enables researchers to better understand the etiology of fat deposition in young children, which can be used to aid in the prevention and treatment of adiposity.

Original languageEnglish (US)
Article numbere0149744
JournalPLoS One
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

sedation
Magnetic resonance
magnetic resonance imaging
Fats
Magnetic Resonance Imaging
image analysis
Imaging techniques
lipids
Liver
scanners
Headphones
testing
Pediatrics
Abdominal Fat
liver
Magnets
Phobic Disorders
Adiposity
adiposity
abdominal fat

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Shearrer, G. E., House, B. T., Gallas, M. C., Luci, J. J., & Davis, J. N. (2016). Fat imaging via magnetic resonance imaging (MRI) in young children (ages 1-4 years) without sedation. PLoS One, 11(2), [e0149744]. https://doi.org/10.1371/journal.pone.0149744

Fat imaging via magnetic resonance imaging (MRI) in young children (ages 1-4 years) without sedation. / Shearrer, Grace E.; House, Benjamin T.; Gallas, Michelle C.; Luci, Jeffrey J.; Davis, Jaimie N.

In: PLoS One, Vol. 11, No. 2, e0149744, 01.02.2016.

Research output: Contribution to journalArticle

Shearrer, Grace E. ; House, Benjamin T. ; Gallas, Michelle C. ; Luci, Jeffrey J. ; Davis, Jaimie N. / Fat imaging via magnetic resonance imaging (MRI) in young children (ages 1-4 years) without sedation. In: PLoS One. 2016 ; Vol. 11, No. 2.
@article{a7fdf3e277634bc691c894ba9cc921f9,
title = "Fat imaging via magnetic resonance imaging (MRI) in young children (ages 1-4 years) without sedation",
abstract = "Introduction: This pilot study developed techniques to perform Magnetic Resonance Imaging (MRI) of specific fat deposition in 18 children (age 18 months to 4 years). Methods: The children engaged in a series of practice tests to become acclimated to the scanner noises, reduce claustrophobia, and rehearse holding still for a set time. The practice tests assessed if the child could remain still for two minutes while watching a video, first while lying on a blanket, second, on the blanket with headphones, and third, in the mock scanner. The children who passed the three practice tests were then scanned with a 3T Siemens Skyra magnet. Abdominal fat distribution (region of interest (ROI) from the top of the ileac crest to the bottom of the ribcage) volume was measured using 2-point DIXON technique. This region was chosen to give an indication of the body composition around the liver. Results: Twelve out of eighteen participants successfully completed the actual MRI scan. Chisquared test showed no significant difference between male and female pass-fail rates. The median age of completed scans was 36 months, whereas the median age for children unable to complete a scan was 28 months. The average total trunk fat was 240.9±85.2mL and the average total VAT was 37.7±25.9mLand liver fat was not quantifiable due to physiological motion. Several strategies (modeling, videos, and incentives) were identified to improve pediatric imaging in different age ranges. Conclusion: Using an age-specific and tailored protocol, we were able to successfully use MRI for fat imaging in a majority of young children. Development of such protocols enables researchers to better understand the etiology of fat deposition in young children, which can be used to aid in the prevention and treatment of adiposity.",
author = "Shearrer, {Grace E.} and House, {Benjamin T.} and Gallas, {Michelle C.} and Luci, {Jeffrey J.} and Davis, {Jaimie N.}",
year = "2016",
month = "2",
day = "1",
doi = "10.1371/journal.pone.0149744",
language = "English (US)",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - Fat imaging via magnetic resonance imaging (MRI) in young children (ages 1-4 years) without sedation

AU - Shearrer, Grace E.

AU - House, Benjamin T.

AU - Gallas, Michelle C.

AU - Luci, Jeffrey J.

AU - Davis, Jaimie N.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Introduction: This pilot study developed techniques to perform Magnetic Resonance Imaging (MRI) of specific fat deposition in 18 children (age 18 months to 4 years). Methods: The children engaged in a series of practice tests to become acclimated to the scanner noises, reduce claustrophobia, and rehearse holding still for a set time. The practice tests assessed if the child could remain still for two minutes while watching a video, first while lying on a blanket, second, on the blanket with headphones, and third, in the mock scanner. The children who passed the three practice tests were then scanned with a 3T Siemens Skyra magnet. Abdominal fat distribution (region of interest (ROI) from the top of the ileac crest to the bottom of the ribcage) volume was measured using 2-point DIXON technique. This region was chosen to give an indication of the body composition around the liver. Results: Twelve out of eighteen participants successfully completed the actual MRI scan. Chisquared test showed no significant difference between male and female pass-fail rates. The median age of completed scans was 36 months, whereas the median age for children unable to complete a scan was 28 months. The average total trunk fat was 240.9±85.2mL and the average total VAT was 37.7±25.9mLand liver fat was not quantifiable due to physiological motion. Several strategies (modeling, videos, and incentives) were identified to improve pediatric imaging in different age ranges. Conclusion: Using an age-specific and tailored protocol, we were able to successfully use MRI for fat imaging in a majority of young children. Development of such protocols enables researchers to better understand the etiology of fat deposition in young children, which can be used to aid in the prevention and treatment of adiposity.

AB - Introduction: This pilot study developed techniques to perform Magnetic Resonance Imaging (MRI) of specific fat deposition in 18 children (age 18 months to 4 years). Methods: The children engaged in a series of practice tests to become acclimated to the scanner noises, reduce claustrophobia, and rehearse holding still for a set time. The practice tests assessed if the child could remain still for two minutes while watching a video, first while lying on a blanket, second, on the blanket with headphones, and third, in the mock scanner. The children who passed the three practice tests were then scanned with a 3T Siemens Skyra magnet. Abdominal fat distribution (region of interest (ROI) from the top of the ileac crest to the bottom of the ribcage) volume was measured using 2-point DIXON technique. This region was chosen to give an indication of the body composition around the liver. Results: Twelve out of eighteen participants successfully completed the actual MRI scan. Chisquared test showed no significant difference between male and female pass-fail rates. The median age of completed scans was 36 months, whereas the median age for children unable to complete a scan was 28 months. The average total trunk fat was 240.9±85.2mL and the average total VAT was 37.7±25.9mLand liver fat was not quantifiable due to physiological motion. Several strategies (modeling, videos, and incentives) were identified to improve pediatric imaging in different age ranges. Conclusion: Using an age-specific and tailored protocol, we were able to successfully use MRI for fat imaging in a majority of young children. Development of such protocols enables researchers to better understand the etiology of fat deposition in young children, which can be used to aid in the prevention and treatment of adiposity.

UR - http://www.scopus.com/inward/record.url?scp=84960539682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960539682&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0149744

DO - 10.1371/journal.pone.0149744

M3 - Article

C2 - 26901881

AN - SCOPUS:84960539682

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e0149744

ER -