Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Juan C. Bernini; Mahmoud M. Mustafa; Laurie J. Sutor; George R. Buchanan

doi:10.1016/S0022-3476(95)70417-5

Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Juan C. Bernini, Mahmoud M. Mustafa, Laurie J. Sutor, George R. Buchanan

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

Original language	English (US)
Pages (from-to)	813-815
Number of pages	3
Journal	The Journal of pediatrics
Volume	126
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(95)70417-5
State	Published - May 1995

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1016/S0022-3476(95)70417-5

Cite this

@article{865b6d3369994565a9f57c588eb1a6d0,

title = "Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia",

abstract = "A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).",

author = "Bernini, {Juan C.} and Mustafa, {Mahmoud M.} and Sutor, {Laurie J.} and Buchanan, {George R.}",

note = "Funding Information: Supported in part by Children's Cancer Fund of Dallas and Consejo Nacional para Investigaciones Cient{\'i}ficas y Tecnologicas, San Jos{\'e}, Costa Rica. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1995",

month = may,

doi = "10.1016/S0022-3476(95)70417-5",

language = "English (US)",

volume = "126",

pages = "813--815",

journal = "The Journal of pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

number = "5",

}

TY - JOUR

T1 - Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

AU - Bernini, Juan C.

AU - Mustafa, Mahmoud M.

AU - Sutor, Laurie J.

AU - Buchanan, George R.

N1 - Funding Information: Supported in part by Children's Cancer Fund of Dallas and Consejo Nacional para Investigaciones Científicas y Tecnologicas, San José, Costa Rica. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1995/5

Y1 - 1995/5

N2 - A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

AB - A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

UR - http://www.scopus.com/inward/record.url?scp=0029034749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029034749&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(95)70417-5

DO - 10.1016/S0022-3476(95)70417-5

M3 - Article

C2 - 7752012

AN - SCOPUS:0029034749

SN - 0022-3476

VL - 126

SP - 813

EP - 815

JO - The Journal of pediatrics

JF - The Journal of pediatrics

IS - 5

ER -

Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this