Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Juan C. Bernini, Mahmoud M. Mustafa, Laurie J. Sutor, George R. Buchanan

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53 Scopus citations


A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

Original languageEnglish (US)
Pages (from-to)813-815
Number of pages3
JournalThe Journal of pediatrics
Issue number5
StatePublished - May 1995


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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