Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Juan C. Bernini, Mahmoud M. Mustafa, Laurie J. Sutor, George R. Buchanan

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

Original languageEnglish (US)
Pages (from-to)813-815
Number of pages3
JournalThe Journal of Pediatrics
Volume126
Issue number5
DOIs
StatePublished - 1995

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Ceftriaxone
Sickle Cell Anemia
Hemolysis
Hemoglobinuria
Antigen-Antibody Complex
Intravenous Administration
Immunoglobulin M
Differential Diagnosis
Erythrocytes
Antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia. / Bernini, Juan C.; Mustafa, Mahmoud M.; Sutor, Laurie J.; Buchanan, George R.

In: The Journal of Pediatrics, Vol. 126, No. 5, 1995, p. 813-815.

Research output: Contribution to journalArticle

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