Fatal hyperleukocytic syndrome in a patient with chronic myelomonocytic leukemia

C. Aul, N. Gattermann, U. Germing, T. Südhoff, K. A. Hollmig, A. Heyll

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A 53-year-old male patient was admitted to our hospital with painful splenomegaly. He was diagnosed as having chronic myelomonocytic leukemia (CMML) with leukocytosis, monocytosis, increased lysozyme concentrations in serum und urine, and lack of the Philadelphia chromosome. The clinical course of the disease was characterized by rapidly rising leukocyte counts, cutaneous infiltrates, respiratory insufficiency and neurological symptoms. Excessive hyperleukocytosis with a significant increase in monocytic cells led to microcirculatory obstruction, vascular endothelial damage and organ malfunction. This complication could not be prevented by low-dose chemotherapy with cytosine arabinoside. The patient finally died from pulmonary and cerebral hyperleukocytic syndrome.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalLeukemia Research
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 1997

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Keywords

  • Chronic myelomonocytic leukemia
  • Hyperleukocytic syndrome
  • Leukocyte adhesion molecules
  • Low-dose chemotherapy
  • Microvascular hyperviscosity
  • Myelodysplastic syndrome
  • Pulmonary circulation

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Aul, C., Gattermann, N., Germing, U., Südhoff, T., Hollmig, K. A., & Heyll, A. (1997). Fatal hyperleukocytic syndrome in a patient with chronic myelomonocytic leukemia. Leukemia Research, 21(3), 249-253. https://doi.org/10.1016/S0145-2126(96)00117-8