TY - JOUR
T1 - Fatty acid oxidation in normotriglyceridemic men
AU - Benjamin, Brian
AU - Wada, Yasuyo
AU - Grundy, Scott M.
AU - Szuszkiewicz-Garcia, Magdalene
AU - Vega, Gloria Lena
N1 - Funding Information:
Dr Benjamin was supported by the Doris Duke Clinical Research Fellowship Program Fund (grant 2010071) for clinical research. Dr Wada was a postdoctoral fellow supported by the Center for Human Nutrition Fellowship. Partial research support for the study was provided by the Southwestern Foundation. Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under award Number UL1TR001105. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. None of the authors have any conflict of interest to declare regarding the current research.
Publisher Copyright:
© 2016 National Lipid Association.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background Moderate hypertriglyceridemia is frequently associated with central obesity, insulin resistance, and atherogenic dyslipidemia. We showed previously that moderately obese men with hypertriglyceridemia have reduced fatty acid oxidation postabsorptively and postprandially. In the present study, we examined the oxidation of fatty acids in normotriglyceridemic men. Objective The study objective was to determine the relation between plasma triglyceride levels and fatty acid oxidation in normotriglyceridemic men. Study design Twenty-four healthy, nonobese White and African American men participated in a cross-sectional metabolic study for evaluation of fatty acid oxidation. Men were healthy, and none took hypolipidemic or hypoglycemic agents. They ingested 200 mg of fat/hour/kg of body weight over a 10-hour period. Plasma levels of triglyceride, nonesterified fatty acids, 3-β-hydroxybutyrate, insulin, and glucagon were measured postabsorptively and postprandially. Chylomicron-triglyceride halflife was also calculated. Results Nonobese White and African-American men had similar anthropometry, levels of plasma triglyceride, lipoprotein cholesterol, nonesterified fatty acids, 3-β-hydroxybutyrate, insulin, and glucagon postabsorptively and postprandially. For the group as a whole, there was a positive and significant correlation between plasma fatty acids and 3-β-hydroxybutyrate and an inverse association between plasma triglyceride levels and 3-β-hydroxybutyrate at baseline. All subjects had increased levels of metabolites of interest postprandially. However, there were no significant changes in plasma insulin, glucagon, or the ratio of insulin to glucagon. The postprandial levels of 3-β-hydroxybutyrate correlated positively with nonesterified fatty acids and inversely with the half-life of chylomicron triglyceride. Conclusion Normotriglyceridemia is strongly associated with oxidation of fatty acids by the liver suggesting the possibility that the fatty acid oxidation pathway is a potential target of intervention to prevent hypertriglyceridemia and concomitant fatty liver.
AB - Background Moderate hypertriglyceridemia is frequently associated with central obesity, insulin resistance, and atherogenic dyslipidemia. We showed previously that moderately obese men with hypertriglyceridemia have reduced fatty acid oxidation postabsorptively and postprandially. In the present study, we examined the oxidation of fatty acids in normotriglyceridemic men. Objective The study objective was to determine the relation between plasma triglyceride levels and fatty acid oxidation in normotriglyceridemic men. Study design Twenty-four healthy, nonobese White and African American men participated in a cross-sectional metabolic study for evaluation of fatty acid oxidation. Men were healthy, and none took hypolipidemic or hypoglycemic agents. They ingested 200 mg of fat/hour/kg of body weight over a 10-hour period. Plasma levels of triglyceride, nonesterified fatty acids, 3-β-hydroxybutyrate, insulin, and glucagon were measured postabsorptively and postprandially. Chylomicron-triglyceride halflife was also calculated. Results Nonobese White and African-American men had similar anthropometry, levels of plasma triglyceride, lipoprotein cholesterol, nonesterified fatty acids, 3-β-hydroxybutyrate, insulin, and glucagon postabsorptively and postprandially. For the group as a whole, there was a positive and significant correlation between plasma fatty acids and 3-β-hydroxybutyrate and an inverse association between plasma triglyceride levels and 3-β-hydroxybutyrate at baseline. All subjects had increased levels of metabolites of interest postprandially. However, there were no significant changes in plasma insulin, glucagon, or the ratio of insulin to glucagon. The postprandial levels of 3-β-hydroxybutyrate correlated positively with nonesterified fatty acids and inversely with the half-life of chylomicron triglyceride. Conclusion Normotriglyceridemia is strongly associated with oxidation of fatty acids by the liver suggesting the possibility that the fatty acid oxidation pathway is a potential target of intervention to prevent hypertriglyceridemia and concomitant fatty liver.
KW - 3-β-hydroxybutyrate
KW - Chylomicron half-life
KW - Fatty acid oxidation
KW - Normotriglyceridemia
KW - Postprandial
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U2 - 10.1016/j.jacl.2015.11.018
DO - 10.1016/j.jacl.2015.11.018
M3 - Article
C2 - 27055958
AN - SCOPUS:84960904369
SN - 1933-2874
VL - 10
SP - 283
EP - 288
JO - Journal of Clinical Lipidology
JF - Journal of Clinical Lipidology
IS - 2
ER -