TY - JOUR
T1 - Fatty liver disease
T2 - MR imaging techniques for the detection and quantification of liver steatosis
AU - Cassidy, Fiona Hughes
AU - Yokoo, Takeshi
AU - Aganovic, Lejla
AU - Hanna, Robert F.
AU - Bydder, Mark
AU - Middleton, Michael S.
AU - Hamilton, Gavin
AU - Chavez, Alyssa D.
AU - Schwimmer, Jeffrey B.
AU - Sirlin, Claude B.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Fatty liver disease is the most common cause of chronic liver disease in the United States. Noninvasive detection and quantification of fat is becoming more and more important clinically, due in large part to the growing prevalence of nonalcoholic fatty liver disease. Steatosis, the accumulation of fat-containing vacuoles within hepatocytes, is a key histologic feature of fatty liver disease. Liver biopsy, the current standard of reference for the assessment of steatosis, is invasive, has sampling errors, and is not appropriate in some settings. Several magnetic resonance (MR) imaging-based techniques-including chemical shift imaging, frequency-selective imaging, and MR spectroscopy-are currently in clinical use for the detection and quantification of fat-water admixtures, with each technique having important advantages, disadvantages, and limitations. These techniques permit the breakdown of the net MR signal into fat and water signal components, allowing the quantification of fat in liver tissue, and are increasingly being used in the diagnosis, treatment, and follow-up of fatty liver disease.
AB - Fatty liver disease is the most common cause of chronic liver disease in the United States. Noninvasive detection and quantification of fat is becoming more and more important clinically, due in large part to the growing prevalence of nonalcoholic fatty liver disease. Steatosis, the accumulation of fat-containing vacuoles within hepatocytes, is a key histologic feature of fatty liver disease. Liver biopsy, the current standard of reference for the assessment of steatosis, is invasive, has sampling errors, and is not appropriate in some settings. Several magnetic resonance (MR) imaging-based techniques-including chemical shift imaging, frequency-selective imaging, and MR spectroscopy-are currently in clinical use for the detection and quantification of fat-water admixtures, with each technique having important advantages, disadvantages, and limitations. These techniques permit the breakdown of the net MR signal into fat and water signal components, allowing the quantification of fat in liver tissue, and are increasingly being used in the diagnosis, treatment, and follow-up of fatty liver disease.
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U2 - 10.1148/rg.291075123
DO - 10.1148/rg.291075123
M3 - Article
C2 - 19168847
AN - SCOPUS:63049091762
SN - 0271-5333
VL - 29
SP - 231
EP - 260
JO - Radiographics
JF - Radiographics
IS - 1
ER -