Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis

Fiona Hughes Cassidy, Takeshi Yokoo, Lejla Aganovic, Robert F. Hanna, Mark Bydder, Michael S. Middleton, Gavin Hamilton, Alyssa D. Chavez, Jeffrey B. Schwimmer, Claude B. Sirlin

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Fatty liver disease is the most common cause of chronic liver disease in the United States. Noninvasive detection and quantification of fat is becoming more and more important clinically, due in large part to the growing prevalence of nonalcoholic fatty liver disease. Steatosis, the accumulation of fat-containing vacuoles within hepatocytes, is a key histologic feature of fatty liver disease. Liver biopsy, the current standard of reference for the assessment of steatosis, is invasive, has sampling errors, and is not appropriate in some settings. Several magnetic resonance (MR) imaging-based techniques-including chemical shift imaging, frequency-selective imaging, and MR spectroscopy-are currently in clinical use for the detection and quantification of fat-water admixtures, with each technique having important advantages, disadvantages, and limitations. These techniques permit the breakdown of the net MR signal into fat and water signal components, allowing the quantification of fat in liver tissue, and are increasingly being used in the diagnosis, treatment, and follow-up of fatty liver disease.

Original languageEnglish (US)
Pages (from-to)231-260
Number of pages30
JournalRadiographics
Volume29
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Fatty Liver
Liver Diseases
Fats
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Water
Selection Bias
Liver
Vacuoles
Hepatocytes
Chronic Disease
Biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Cassidy, F. H., Yokoo, T., Aganovic, L., Hanna, R. F., Bydder, M., Middleton, M. S., ... Sirlin, C. B. (2009). Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics, 29(1), 231-260. https://doi.org/10.1148/rg.291075123

Fatty liver disease : MR imaging techniques for the detection and quantification of liver steatosis. / Cassidy, Fiona Hughes; Yokoo, Takeshi; Aganovic, Lejla; Hanna, Robert F.; Bydder, Mark; Middleton, Michael S.; Hamilton, Gavin; Chavez, Alyssa D.; Schwimmer, Jeffrey B.; Sirlin, Claude B.

In: Radiographics, Vol. 29, No. 1, 01.2009, p. 231-260.

Research output: Contribution to journalArticle

Cassidy, FH, Yokoo, T, Aganovic, L, Hanna, RF, Bydder, M, Middleton, MS, Hamilton, G, Chavez, AD, Schwimmer, JB & Sirlin, CB 2009, 'Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis', Radiographics, vol. 29, no. 1, pp. 231-260. https://doi.org/10.1148/rg.291075123
Cassidy, Fiona Hughes ; Yokoo, Takeshi ; Aganovic, Lejla ; Hanna, Robert F. ; Bydder, Mark ; Middleton, Michael S. ; Hamilton, Gavin ; Chavez, Alyssa D. ; Schwimmer, Jeffrey B. ; Sirlin, Claude B. / Fatty liver disease : MR imaging techniques for the detection and quantification of liver steatosis. In: Radiographics. 2009 ; Vol. 29, No. 1. pp. 231-260.
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