FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Donita R. Croft; John Trapp; Kemp Kernstine; Peter Kirchner; Brian Mullan; Jeffery Galvin; Michael W. Peterson; Thomas Gross; Geoffrey McLennan; Jeffrey A. Kern

doi:10.1016/S0169-5002(02)00023-5

FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Donita R. Croft, John Trapp, Kemp Kernstine, Peter Kirchner, Brian Mullan, Jeffery Galvin, Michael W. Peterson, Thomas Gross, Geoffrey McLennan, Jeffrey A. Kern

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Study objective: Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy-D-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis. Design: Prospective, clinical study. Setting: University, tertiary referral hospital in the upper Mississippi River valley. Patients: Ninety patients with SPNs. Interventions: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs. Measurements and results: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%. Conclusions: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC.In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.

Original language	English (US)
Pages (from-to)	297-301
Number of pages	5
Journal	Lung Cancer
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/S0169-5002(02)00023-5
State	Published - 2002

Keywords

Carcinoma non-small-cell lung
Computed tomography
Histoplasmosis
Infection, fungal
Lung neoplasms
Positron-emission tomography
Pulmonary nodule solitary

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.1016/S0169-5002(02)00023-5

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title = "FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence",

abstract = "Study objective: Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy-D-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis. Design: Prospective, clinical study. Setting: University, tertiary referral hospital in the upper Mississippi River valley. Patients: Ninety patients with SPNs. Interventions: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs. Measurements and results: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%. Conclusions: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC.In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.",

keywords = "Carcinoma non-small-cell lung, Computed tomography, Histoplasmosis, Infection, fungal, Lung neoplasms, Positron-emission tomography, Pulmonary nodule solitary",

author = "Croft, {Donita R.} and John Trapp and Kemp Kernstine and Peter Kirchner and Brian Mullan and Jeffery Galvin and Peterson, {Michael W.} and Thomas Gross and Geoffrey McLennan and Kern, {Jeffrey A.}",

year = "2002",

doi = "10.1016/S0169-5002(02)00023-5",

language = "English (US)",

volume = "36",

pages = "297--301",

journal = "Lung Cancer",

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T1 - FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

AU - Croft, Donita R.

AU - Trapp, John

AU - Kernstine, Kemp

AU - Kirchner, Peter

AU - Mullan, Brian

AU - Galvin, Jeffery

AU - Peterson, Michael W.

AU - Gross, Thomas

AU - McLennan, Geoffrey

AU - Kern, Jeffrey A.

PY - 2002

Y1 - 2002

N2 - Study objective: Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy-D-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis. Design: Prospective, clinical study. Setting: University, tertiary referral hospital in the upper Mississippi River valley. Patients: Ninety patients with SPNs. Interventions: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs. Measurements and results: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%. Conclusions: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC.In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.

AB - Study objective: Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy-D-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis. Design: Prospective, clinical study. Setting: University, tertiary referral hospital in the upper Mississippi River valley. Patients: Ninety patients with SPNs. Interventions: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs. Measurements and results: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%. Conclusions: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC.In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.

KW - Carcinoma non-small-cell lung

KW - Computed tomography

KW - Histoplasmosis

KW - Infection, fungal

KW - Lung neoplasms

KW - Positron-emission tomography

KW - Pulmonary nodule solitary

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FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Abstract

Keywords

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