Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors

M. E. Horowitz, L. E. Kun, R. K. Mulhern, E. H. Kovnar, R. A. Sanford, B. M. Hockenberger, F. L. Greeson, J. W. Langston, D. L. Fairclough, J. J. Jenkins

Research output: Contribution to journalArticle

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Abstract

Preirradiation chemotherapy is a potentially important component of combined treatment for brain tumors; however, concerns over its side effects and antitumor activity have impeded its evaluation in clinical trials. To determine the feasibility of administering such therapy to children, we assessed the responses of 38 brain tumor patients (median age, 2 years) to 12 weeks of combination chemotherapy given after surgical resection but before irradiation. Transient myelosuppression was noted in all patients, but was not associated with infections or complications of surgical wounds. The ability of the patients to perform activities of daily life, as rated with the Karnofsky performance scale, was either improved (n = 14) or unchanged (n = 18) at the end of the evaluation period. In the remainder of the group, functional deterioration was clearly related to causes other than drug treatment. Prior chemotherapy did not compromise the delivery of radiation except for a brief interruption of spinal irradiation in 3 patients. Objective responses to chemotherapy, defined as >50% decrease in tumor masses, occurred in 16 of the 31 patients who had subtotal resections; only 6 patients in the entire group showed disease progression during the 12 weeks of drug administration. We conclude that chemotherapy of the type used in this study is well tolerated and produces beneficial effects in children with brain tumors.

Original languageEnglish (US)
Pages (from-to)687-690
Number of pages4
JournalNeurosurgery
Volume22
Issue number4
DOIs
StatePublished - Jan 1 1988

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Brain Neoplasms
Pediatrics
Drug Therapy
Karnofsky Performance Status
Combination Drug Therapy
Pharmaceutical Preparations
Disease Progression
Therapeutics
Clinical Trials
Radiation
Infection
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Horowitz, M. E., Kun, L. E., Mulhern, R. K., Kovnar, E. H., Sanford, R. A., Hockenberger, B. M., ... Jenkins, J. J. (1988). Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors. Neurosurgery, 22(4), 687-690. https://doi.org/10.1227/00006123-198804000-00011

Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors. / Horowitz, M. E.; Kun, L. E.; Mulhern, R. K.; Kovnar, E. H.; Sanford, R. A.; Hockenberger, B. M.; Greeson, F. L.; Langston, J. W.; Fairclough, D. L.; Jenkins, J. J.

In: Neurosurgery, Vol. 22, No. 4, 01.01.1988, p. 687-690.

Research output: Contribution to journalArticle

Horowitz, ME, Kun, LE, Mulhern, RK, Kovnar, EH, Sanford, RA, Hockenberger, BM, Greeson, FL, Langston, JW, Fairclough, DL & Jenkins, JJ 1988, 'Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors', Neurosurgery, vol. 22, no. 4, pp. 687-690. https://doi.org/10.1227/00006123-198804000-00011
Horowitz ME, Kun LE, Mulhern RK, Kovnar EH, Sanford RA, Hockenberger BM et al. Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors. Neurosurgery. 1988 Jan 1;22(4):687-690. https://doi.org/10.1227/00006123-198804000-00011
Horowitz, M. E. ; Kun, L. E. ; Mulhern, R. K. ; Kovnar, E. H. ; Sanford, R. A. ; Hockenberger, B. M. ; Greeson, F. L. ; Langston, J. W. ; Fairclough, D. L. ; Jenkins, J. J. / Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors. In: Neurosurgery. 1988 ; Vol. 22, No. 4. pp. 687-690.
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