Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease

Emil Achmad, Takeshi Yokoo, Gavin Hamilton, Elhamy R. Heba, Jonathan C. Hooker, Christopher Changchien, Michael Schroeder, Tanya Wolfson, Anthony Gamst, Jeffrey B. Schwimmer, Joel E. Lavine, Claude B. Sirlin, Michael S. Middleton

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Purpose: To assess feasibility of and agreement between magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for estimating hepatic proton density fat fraction (PDFF) in children with known or suspected nonalcoholic fatty liver disease (NAFLD). Materials and methods: Children were included in this study from two previous research studies in each of which three MRI and three MRS acquisitions were obtained. Sequence acceptability, and MRI- and MRS-estimated PDFF were evaluated. Agreement of MRI- with MRS-estimated hepatic PDFF was assessed by linear regression and Bland–Altman analysis. Age, sex, BMI-Z score, acquisition time, and artifact score effects on MRI- and MRS-estimated PDFF agreement were assessed by multiple linear regression. Results: Eighty-six children (61 boys and 25 girls) were included in this study. Slope and intercept from regressing MRS-PDFF on MRI-PDFF were 0.969 and 1.591%, respectively, and the Bland–Altman bias and 95% limits of agreement were 1.17% ± 2.61%. MRI motion artifact score was higher in boys than girls (by 0.21, p = 0.021). Higher BMI-Z score was associated with lower agreement between MRS and MRI (p = 0.045). Conclusion: Hepatic PDFF estimation by both MRI and MRS is feasible, and MRI- and MRS-estimated PDFF agree closely in children with known or suspected NAFLD.

Original languageEnglish (US)
Pages (from-to)3084-3090
Number of pages7
JournalAbdominal Imaging
Volume40
Issue number8
DOIs
StatePublished - Jul 25 2015

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Keywords

  • MRI
  • MRS
  • NAFLD
  • PDFF
  • Proton density fat fraction
  • Steatosis

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Achmad, E., Yokoo, T., Hamilton, G., Heba, E. R., Hooker, J. C., Changchien, C., Schroeder, M., Wolfson, T., Gamst, A., Schwimmer, J. B., Lavine, J. E., Sirlin, C. B., & Middleton, M. S. (2015). Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease. Abdominal Imaging, 40(8), 3084-3090. https://doi.org/10.1007/s00261-015-0506-9