Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits

Thomas K. Rhee; Andrew C. Larson; Pottumarthi V. Prasad; Elizabette Santos; Kent T. Sato; Riad Salem; Jie Deng; Tatjana Paunesku; Gayle E. Woloschak; Mary F. Mulcahy; Debiao Li; Reed A. Omary

doi:10.1097/01.RVI.0000182179.87340.D7

Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits

Thomas K. Rhee, Andrew C. Larson, Pottumarthi V. Prasad, Elizabette Santos, Kent T. Sato, Riad Salem, Jie Deng, Tatjana Paunesku, Gayle E. Woloschak, Mary F. Mulcahy, Debiao Li, Reed A. Omary

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30 Scopus citations

Abstract

Blood oxygenation level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method to assess changes in oxygen delivery to tissues. It was hypothesized that BOLD MR imaging can detect changes in rabbit VX2 liver tumor oxygenation after hepatic artery embolization with polyvinyl alcohol particles. In four discrete VX2 liver tumors, a statistically significant mean reduction in apparent transverse relaxation time was shown, from 55 milli-seconds before embolization to 41 milliseconds after embolization (P < .01). This reduction corresponded to a decrease in hepatic tumor oxygenation. The use of BOLD MR imaging to monitor changes in hepatic tumor oxygenation after embolization is feasible. These functional MR imaging measurements of hypoxia may be targeted as an endpoint for therapy in future studies.

Original language	English (US)
Pages (from-to)	1523-1528
Number of pages	6
Journal	Journal of Vascular and Interventional Radiology
Volume	16
Issue number	11
DOIs	https://doi.org/10.1097/01.RVI.0000182179.87340.D7
State	Published - Nov 2005
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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Rhee, T. K., Larson, A. C., Prasad, P. V., Santos, E., Sato, K. T., Salem, R., Deng, J., Paunesku, T., Woloschak, G. E., Mulcahy, M. F., Li, D., & Omary, R. A. (2005). Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits. Journal of Vascular and Interventional Radiology, 16(11), 1523-1528. https://doi.org/10.1097/01.RVI.0000182179.87340.D7

Rhee, TK, Larson, AC, Prasad, PV, Santos, E, Sato, KT, Salem, R, Deng, J, Paunesku, T, Woloschak, GE, Mulcahy, MF, Li, D & Omary, RA 2005, 'Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits', Journal of Vascular and Interventional Radiology, vol. 16, no. 11, pp. 1523-1528. https://doi.org/10.1097/01.RVI.0000182179.87340.D7

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title = "Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits",

abstract = "Blood oxygenation level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method to assess changes in oxygen delivery to tissues. It was hypothesized that BOLD MR imaging can detect changes in rabbit VX2 liver tumor oxygenation after hepatic artery embolization with polyvinyl alcohol particles. In four discrete VX2 liver tumors, a statistically significant mean reduction in apparent transverse relaxation time was shown, from 55 milli-seconds before embolization to 41 milliseconds after embolization (P < .01). This reduction corresponded to a decrease in hepatic tumor oxygenation. The use of BOLD MR imaging to monitor changes in hepatic tumor oxygenation after embolization is feasible. These functional MR imaging measurements of hypoxia may be targeted as an endpoint for therapy in future studies.",

author = "Rhee, {Thomas K.} and Larson, {Andrew C.} and Prasad, {Pottumarthi V.} and Elizabette Santos and Sato, {Kent T.} and Riad Salem and Jie Deng and Tatjana Paunesku and Woloschak, {Gayle E.} and Mulcahy, {Mary F.} and Debiao Li and Omary, {Reed A.}",

note = "Funding Information: R.A.O. was supported in part by NIH grant K08 DK60020. None of the authors have identified a conflict of interest. ",

year = "2005",

month = nov,

doi = "10.1097/01.RVI.0000182179.87340.D7",

language = "English (US)",

volume = "16",

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AU - Rhee, Thomas K.

AU - Larson, Andrew C.

AU - Prasad, Pottumarthi V.

AU - Santos, Elizabette

AU - Sato, Kent T.

AU - Salem, Riad

AU - Deng, Jie

AU - Paunesku, Tatjana

AU - Woloschak, Gayle E.

AU - Mulcahy, Mary F.

AU - Li, Debiao

AU - Omary, Reed A.

N1 - Funding Information: R.A.O. was supported in part by NIH grant K08 DK60020. None of the authors have identified a conflict of interest.

PY - 2005/11

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N2 - Blood oxygenation level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method to assess changes in oxygen delivery to tissues. It was hypothesized that BOLD MR imaging can detect changes in rabbit VX2 liver tumor oxygenation after hepatic artery embolization with polyvinyl alcohol particles. In four discrete VX2 liver tumors, a statistically significant mean reduction in apparent transverse relaxation time was shown, from 55 milli-seconds before embolization to 41 milliseconds after embolization (P < .01). This reduction corresponded to a decrease in hepatic tumor oxygenation. The use of BOLD MR imaging to monitor changes in hepatic tumor oxygenation after embolization is feasible. These functional MR imaging measurements of hypoxia may be targeted as an endpoint for therapy in future studies.

AB - Blood oxygenation level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method to assess changes in oxygen delivery to tissues. It was hypothesized that BOLD MR imaging can detect changes in rabbit VX2 liver tumor oxygenation after hepatic artery embolization with polyvinyl alcohol particles. In four discrete VX2 liver tumors, a statistically significant mean reduction in apparent transverse relaxation time was shown, from 55 milli-seconds before embolization to 41 milliseconds after embolization (P < .01). This reduction corresponded to a decrease in hepatic tumor oxygenation. The use of BOLD MR imaging to monitor changes in hepatic tumor oxygenation after embolization is feasible. These functional MR imaging measurements of hypoxia may be targeted as an endpoint for therapy in future studies.

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Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits

Abstract

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