TY - JOUR
T1 - Feasibility of cardiovascular four-dimensional flow mri during exercise in healthy participants
AU - Macdonald, Jacob A.
AU - Beshish, Arij G.
AU - Corrado, Philip A.
AU - Barton, Gregory P.
AU - Goss, Kara N.
AU - Eldridge, Marlowe W.
AU - François, Christopher J.
AU - Wieben, Oliver
N1 - Funding Information:
Acknowledgments: We gratefully ac knowledge funding from the NIH and research support from GE Healthcare.
Funding Information:
J.A.M. disclosed no relevant relation- ships. A.G.B. disclosed no relevant re-lationships. P.A.C. Activities related to the present article: supported by two National Institutes of Health awards (UL1TR000427 and TL1TR000429) as a predoctoral trainee. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. G.P.B. Activities related to the present article: employed by University of Wisconsin-Madison. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. K.N.G. disclosed no relevant relationships. M.W.E. Activities related to the present article: institution received a grant from the National Institutes of Health. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. C.J.F. Activities related to the present article: institution received grant from the National Institutes of Health. Activities not related to the present article: grant to institution from GE Healthcare. Other relationships: disclosed no relevant relationships. O.W. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: insti- tution received research support from GE Healthcare. Other relationships: disclosed no relevant relationships.
Funding Information:
From the Departments of Medical Physics (J.A.M., P.A.C., O.W.), Pediatrics (A.G.B., G.P.B., K.N.G., M.W.E.), Medicine (K.N.G.), Biomedical Engineering (M.W.E., O.W.), and Radiology (C.J.F., O.W.), University of Wisconsin, 1111 Highland Ave, Room 1005, Madison, WI 53705. Received February 19, 2019; revision requested May 14; revision received November 4; accepted December 23. Address correspondence to J.A.M. (e-mail: jamacdonald@wisc.edu). Supported by the National Institutes of Health (R01 HL086897, R01 HL38149). Conflicts of interest are listed at the end of this article.
Publisher Copyright:
© RSNA, 2020.
PY - 2020/6
Y1 - 2020/6
N2 - Purpose: To explore the feasibility of using four-dimensional (4D) flow MRI to quantify blood flow and kinetic energy (KE) in the heart during strenuous exercise. Materials and Methods: For this prospective study, cardiac 4D flow MRI was performed in 11 healthy young adult participants (eight men, three women; mean age, 26 years ± 1 [standard deviation]) at rest and during exercise with an MRI-compatible exercise step-per between March 2016 and July 2017. Flow was measured in the ascending aorta (AAo) and main pulmonary artery (MPA). KE was quantified in the left and right ventricle. Significant changes in flow and KE during exercise were identified by using t tests. Repeatability was assessed with inter-and intraobserver comparisons and an analysis of internal flow consistency. Results: Nine participants successfully completed both rest and exercise imaging. Internal flow consistency analysis in systemic and pulmonary circulation showed average relative differences of 10% at rest and 16% during exercise. For flow measurements in the AAo and MPA, relative differences between observers never exceeded 6% in any vessel and showed excellent correlation, even during exercise. Relative differences were increased for KE, typically on the order of 30%, with poor interobserver correlation between measurements. Conclusion: Four-dimensional flow MRI can quantify increases in flow in the AAo and MPA during strenuous exercise and is highly repeatable. KE had reduced repeatability because of suboptimal segmentation methods and requires further development before clinical implementation.
AB - Purpose: To explore the feasibility of using four-dimensional (4D) flow MRI to quantify blood flow and kinetic energy (KE) in the heart during strenuous exercise. Materials and Methods: For this prospective study, cardiac 4D flow MRI was performed in 11 healthy young adult participants (eight men, three women; mean age, 26 years ± 1 [standard deviation]) at rest and during exercise with an MRI-compatible exercise step-per between March 2016 and July 2017. Flow was measured in the ascending aorta (AAo) and main pulmonary artery (MPA). KE was quantified in the left and right ventricle. Significant changes in flow and KE during exercise were identified by using t tests. Repeatability was assessed with inter-and intraobserver comparisons and an analysis of internal flow consistency. Results: Nine participants successfully completed both rest and exercise imaging. Internal flow consistency analysis in systemic and pulmonary circulation showed average relative differences of 10% at rest and 16% during exercise. For flow measurements in the AAo and MPA, relative differences between observers never exceeded 6% in any vessel and showed excellent correlation, even during exercise. Relative differences were increased for KE, typically on the order of 30%, with poor interobserver correlation between measurements. Conclusion: Four-dimensional flow MRI can quantify increases in flow in the AAo and MPA during strenuous exercise and is highly repeatable. KE had reduced repeatability because of suboptimal segmentation methods and requires further development before clinical implementation.
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U2 - 10.1148/ryct.2020190033
DO - 10.1148/ryct.2020190033
M3 - Article
C2 - 32734274
AN - SCOPUS:85101885554
SN - 2638-6135
VL - 2
JO - Radiology: Cardiothoracic Imaging
JF - Radiology: Cardiothoracic Imaging
IS - 3
M1 - e190033
ER -