Feasibility of combining MR perfusion, angiography, and 3He ventilation imaging for evaluation of lung function in a porcine model

Cheng Hong, Jason C. Leawoods, Dmitriy A. Yablonskiy, John R. Leyendecker, Kyongtae T. Bae, Thomas K. Pilgram, Pamela K. Woodard, Mark S. Conradi, Jie Zheng

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Rationale and Objective. To assess the feasibility of combining magnetic resonance (MR) perfusion, angiography, and 3He ventilation imaging for the evaluation of lung function in a porcine model. Materials and Methods. Fourteen consecutive porcine models with externally delivered pulmonary emboli and/or airway occlusions were examined with MR perfusion, angiography, and 3He ventilation imaging. Ultrafast gradient-echo sequences were used for 3D perfusion and angiographic imaging, in conjunction with the use of contrast-agent injections. 2D multiple-section 3He imaging was performed subsequently via the inhalation of hyperpolarized 3He gas. The diagnostic accuracy of MR angiography for detecting pulmonary emboli was determined by two reviewers. The diagnostic confidence for different combinations of MR techniques was rated on the basis of a 5-point grading scale (5 = definite). Results. The sensitivity, specificity, and accuracy of MR angiography for detecting pulmonary emboli were approximately 85.7%, 90.5%, and 88.1%, respectively. The interobserver agreement was very strong (k = 0.82). There was a clear tendency for confidence to increase when first perfusion and then ventilation imaging were added to the angiographic image (Wilcoxon signed ranks test, P = 0.03). Conclusion. The combination of the three methods of MR perfusion, angiography, and 3H ventilation imaging may provide complementary information on abnormal lung anatomy and function.

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalAcademic radiology
Volume12
Issue number2
DOIs
StatePublished - Feb 2005

Keywords

  • Angiography
  • Lung perfusion
  • Lung ventilation
  • Magnetic resonance
  • Pulmonary embolism

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Hong, C., Leawoods, J. C., Yablonskiy, D. A., Leyendecker, J. R., Bae, K. T., Pilgram, T. K., Woodard, P. K., Conradi, M. S., & Zheng, J. (2005). Feasibility of combining MR perfusion, angiography, and 3He ventilation imaging for evaluation of lung function in a porcine model. Academic radiology, 12(2), 202-209. https://doi.org/10.1016/j.acra.2004.11.021