Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer

Robert Staruch, Laura Curiel, Rajiv Chopra, Kullervo Hynynena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High cure rates for testicular cancer have prompted interest in organ-sparing surgery for patients with bilateral disease or single testis. Focused ultrasound (FUS) ablation could offer a noninvasive approach to organ-sparing surgery. The objective of this study was to determine the feasibility of using MR thermometry to guide organ-sparing focused ultrasound surgery in the testis. The testes of anesthetized rabbits were sonicated in several discrete locations using a single-element focused transducer operating at 2.787MHz. Focal heating was visualized with MR thermometry, using a measured PRF thermal coefficient of -0.0089 ± 0.0003 ppm/°C. Sonications at 3.5-14 acoustic watts applied for 30 seconds produced maximum temperature elevations of 10-80°C, with coagulation verified by histology. Coagulation of precise volumes in the testicle is feasible with MRI-guided focused ultrasound. Variability in peak temperature for given sonication parameters suggests the need for online temperature feedback control.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages134-138
Number of pages5
Volume1113
DOIs
StatePublished - 2009
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Other

Other8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

Fingerprint

testes
surgery
organs
cancer
coagulation
temperature measurement
histology
rabbits
feedback control
ablation
temperature
transducers
heating
acoustics
coefficients

Keywords

  • Focused ultrasound
  • MRI
  • Proton resonance frequency shift
  • Testis
  • Thermometry

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Staruch, R., Curiel, L., Chopra, R., & Hynynena, K. (2009). Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer. In AIP Conference Proceedings (Vol. 1113, pp. 134-138) https://doi.org/10.1063/1.3131398

Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer. / Staruch, Robert; Curiel, Laura; Chopra, Rajiv; Hynynena, Kullervo.

AIP Conference Proceedings. Vol. 1113 2009. p. 134-138.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Staruch, R, Curiel, L, Chopra, R & Hynynena, K 2009, Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer. in AIP Conference Proceedings. vol. 1113, pp. 134-138, 8th International Symposium on Therapeutic Ultrasound, Minneapolis, MN, United States, 9/10/08. https://doi.org/10.1063/1.3131398
Staruch R, Curiel L, Chopra R, Hynynena K. Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer. In AIP Conference Proceedings. Vol. 1113. 2009. p. 134-138 https://doi.org/10.1063/1.3131398
Staruch, Robert ; Curiel, Laura ; Chopra, Rajiv ; Hynynena, Kullervo. / Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer. AIP Conference Proceedings. Vol. 1113 2009. pp. 134-138
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