Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer

Robert Staruch, Laura Curiel, Rajiv Chopra, Kullervo Hynynena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High cure rates for testicular cancer have prompted interest in organ-sparing surgery for patients with bilateral disease or single testis. Focused ultrasound (FUS) ablation could offer a noninvasive approach to organ-sparing surgery. The objective of this study was to determine the feasibility of using MR thermometry to guide organ-sparing focused ultrasound surgery in the testis. The testes of anesthetized rabbits were sonicated in several discrete locations using a single-element focused transducer operating at 2.787MHz. Focal heating was visualized with MR thermometry, using a measured PRF thermal coefficient of -0.0089 ± 0.0003 ppm/°C. Sonications at 3.5-14 acoustic watts applied for 30 seconds produced maximum temperature elevations of 10-80°C, with coagulation verified by histology. Coagulation of precise volumes in the testicle is feasible with MRI-guided focused ultrasound. Variability in peak temperature for given sonication parameters suggests the need for online temperature feedback control.

Original languageEnglish (US)
Title of host publication8th International Symposium on Therapeutic Ultrasound
Pages134-138
Number of pages5
DOIs
StatePublished - Jul 21 2009
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Publication series

NameAIP Conference Proceedings
Volume1113
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

Keywords

  • Focused ultrasound
  • MRI
  • Proton resonance frequency shift
  • Testis
  • Thermometry

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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