TY - JOUR
T1 - Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex
AU - Dvorkin, Anna
AU - Silva, Charmaine
AU - McMurran, Thomas
AU - Bisnaire, Liane
AU - Foster, Jane
AU - Szechtman, Henry
PY - 2010/11
Y1 - 2010/11
N2 - The quinpirole sensitization model of obsessive-compulsive disorder was used to investigate the functional role that brain regions implicated in a neuroanatomical circuit of obsessive-compulsive disorder may play in compulsive checking behavior. Following repeated injections of saline or quinpirole (0.5 mg/kg, twice per week, ×8 injections) to induce compulsive checking, rats received N-methyl-d-aspartate lesions of the nucleus accumbens core (NAc), orbital frontal cortex (OFC) and basolateral amygdala, or sham lesions. When retested at 17 days post-surgery, the results showed effects of NAc and OFC but not basolateral amygdala lesion. NAc lesions affected measures indicative of the amount of checking behavior, whereas OFC lesions affected indices of staying away from checking. The pattern of results suggested that the functional roles of the NAc and OFC in checking behavior are to control the vigor of motor performance and focus on goal-directed activity, respectively. Furthermore, similarities in behavior between quinpirole sham rats and saline NAc lesion rats suggested that quinpirole may drive the vigor of checking by inhibition of NAc neurons, and that the NAc may be a site for the negative feedback control of checking.
AB - The quinpirole sensitization model of obsessive-compulsive disorder was used to investigate the functional role that brain regions implicated in a neuroanatomical circuit of obsessive-compulsive disorder may play in compulsive checking behavior. Following repeated injections of saline or quinpirole (0.5 mg/kg, twice per week, ×8 injections) to induce compulsive checking, rats received N-methyl-d-aspartate lesions of the nucleus accumbens core (NAc), orbital frontal cortex (OFC) and basolateral amygdala, or sham lesions. When retested at 17 days post-surgery, the results showed effects of NAc and OFC but not basolateral amygdala lesion. NAc lesions affected measures indicative of the amount of checking behavior, whereas OFC lesions affected indices of staying away from checking. The pattern of results suggested that the functional roles of the NAc and OFC in checking behavior are to control the vigor of motor performance and focus on goal-directed activity, respectively. Furthermore, similarities in behavior between quinpirole sham rats and saline NAc lesion rats suggested that quinpirole may drive the vigor of checking by inhibition of NAc neurons, and that the NAc may be a site for the negative feedback control of checking.
KW - Animal model
KW - D2/D3 dopamine agonist
KW - Obsessive-compulsive disorder
KW - Quinpirole
KW - Rat
KW - Security motivation
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UR - http://www.scopus.com/inward/citedby.url?scp=78149255370&partnerID=8YFLogxK
U2 - 10.1111/j.1460-9568.2010.07398.x
DO - 10.1111/j.1460-9568.2010.07398.x
M3 - Article
C2 - 20731708
AN - SCOPUS:78149255370
SN - 0953-816X
VL - 32
SP - 1552
EP - 1563
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 9
ER -