ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА

Y. V. Gorina; A. B. Salmina; D. P. Chernyuk; A. V. Bolshakova; P. M. Balaban; I. B. Bezprozvanny; O. L. Vlasova

doi:10.31857/S0044467721050051

ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА

Translated title of the contribution: FEATURES OF THE DEVELOPMENT AND ANALYSIS OF DISORDERS OF SOCIAL BEHAVIOR AND COGNITD7E FUNCTIONS IN ANIMALS WITH EXPERIMENTAL ALZHEIMER'S DISEASE

Y. V. Gorina, A. B. Salmina, D. P. Chernyuk, A. V. Bolshakova, P. M. Balaban, I. B. Bezprozvanny, O. L. Vlasova

Research output: Contribution to journal › Article › peer-review

Abstract

Alzheimer's disease is the most common neurodegenerative disease worldwide, with significant negative social and economic consequences. Despite numerous studies of the pathogenesis of the disease, neuropathological mechanisms remain completely unclear, and modern methods of treatment are not sufficiently effective. In recent decades, genetic models of Alzheimer's disease in rodents have been used to study in detail the molecular mechanisms of the disease. This is critical for her early diagnosis and effective therapy. Taking into account the significant effect of beta-amyloid on the manifestation of behavioral disorders and the development of cognitive dysfunction, in this review we present a detailed characterization of the transgenic 5xFAD mouse model as the most valuable and necessary tool for studying the main mechanisms underlying cognitive and mental disorders in Alzheimer's disease, as well as their relationship with the cerebral microenvironment.

Translated title of the contribution	FEATURES OF THE DEVELOPMENT AND ANALYSIS OF DISORDERS OF SOCIAL BEHAVIOR AND COGNITD7E FUNCTIONS IN ANIMALS WITH EXPERIMENTAL ALZHEIMER'S DISEASE
Original language	Russian
Pages (from-to)	667-679
Number of pages	13
Journal	Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume	71
Issue number	5
DOIs	https://doi.org/10.31857/S0044467721050051
State	Published - 2021

Keywords

5xFAD mouse model
Alzheimer's disease
behavior
genetic models in rodents

ASJC Scopus subject areas

General Neuroscience

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10.31857/S0044467721050051

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Gorina, Y. V., Salmina, A. B., Chernyuk, D. P., Bolshakova, A. V., Balaban, P. M., Bezprozvanny, I. B., & Vlasova, O. L. (2021). ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, 71(5), 667-679. https://doi.org/10.31857/S0044467721050051

ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА. / Gorina, Y. V.; Salmina, A. B.; Chernyuk, D. P. et al.
In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 71, No. 5, 2021, p. 667-679.

Research output: Contribution to journal › Article › peer-review

Gorina, YV, Salmina, AB, Chernyuk, DP, Bolshakova, AV, Balaban, PM, Bezprozvanny, IB & Vlasova, OL 2021, 'ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА', Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, vol. 71, no. 5, pp. 667-679. https://doi.org/10.31857/S0044467721050051

Gorina YV, Salmina AB, Chernyuk DP, Bolshakova AV, Balaban PM, Bezprozvanny IB et al. ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2021;71(5):667-679. doi: 10.31857/S0044467721050051

Gorina, Y. V. ; Salmina, A. B. ; Chernyuk, D. P. et al. / ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА. In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2021 ; Vol. 71, No. 5. pp. 667-679.

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ОСОБЕННОСТИ РАЗВИТИЯ И АНАЛИЗА НАРУШЕНИЙ СОЦИАЛЬНОГО ПОВЕДЕНИЯ И КОГНИТИВНЫХ ФУНКЦИЙ У ЖИВОТНЫХ С ЭКСПЕРИМЕНТАЛЬНОЙ БОЛЕЗНЬЮ АЛЬЦГЕЙМЕРА

Abstract

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ASJC Scopus subject areas

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