Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity

D. Elahi, M. Nagulesparan, R. J. Hershcopf, D. C. Muller, J. D. Tobin, P. M. Blix, A. H. Rubenstein, Roger H Unger, R. Andres

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

We investigated the possible existence of a negative short-loop feedback of circulating insulin on the parent beta cell in 10 lean Caucasians, 10 obese Caucasians, and 10 obese Pima Indians. Plasma insulin levels were raised acutely by 100 μU per milliliter for 90 minutes, and plasma glucose was maintained by the 'clamp' technique. C-peptide levels were 0,2166 suppressed in all groups to approximately 50 per cent of basal values. However, the obese groups had absolute C-peptide levels much higher than those of the lean group. During the hour after infusion, the rate and magnitude of C-peptide recovery in the obese groups were higher than in the lean group. Thus, negative short-loop insulin-beta-cell feedback was operative in both the lean and obese states. Despite this suppression, the insulin-secretion rate in obese subjects was still greater than that in 0,2671 non-obese subjects. Inadequate feedback suppression may account in part for the prevailing hyperinsulinemia of the obese.

Original languageEnglish (US)
Pages (from-to)1196-1202
Number of pages7
JournalNew England Journal of Medicine
Volume306
Issue number20
StatePublished - 1982

Fingerprint

Hyperinsulinism
C-Peptide
Obesity
Insulin
Potassium Iodide
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Elahi, D., Nagulesparan, M., Hershcopf, R. J., Muller, D. C., Tobin, J. D., Blix, P. M., ... Andres, R. (1982). Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity. New England Journal of Medicine, 306(20), 1196-1202.

Feedback inhibition of insulin secretion by insulin : Relation to the hyperinsulinemia of obesity. / Elahi, D.; Nagulesparan, M.; Hershcopf, R. J.; Muller, D. C.; Tobin, J. D.; Blix, P. M.; Rubenstein, A. H.; Unger, Roger H; Andres, R.

In: New England Journal of Medicine, Vol. 306, No. 20, 1982, p. 1196-1202.

Research output: Contribution to journalArticle

Elahi, D, Nagulesparan, M, Hershcopf, RJ, Muller, DC, Tobin, JD, Blix, PM, Rubenstein, AH, Unger, RH & Andres, R 1982, 'Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity', New England Journal of Medicine, vol. 306, no. 20, pp. 1196-1202.
Elahi D, Nagulesparan M, Hershcopf RJ, Muller DC, Tobin JD, Blix PM et al. Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity. New England Journal of Medicine. 1982;306(20):1196-1202.
Elahi, D. ; Nagulesparan, M. ; Hershcopf, R. J. ; Muller, D. C. ; Tobin, J. D. ; Blix, P. M. ; Rubenstein, A. H. ; Unger, Roger H ; Andres, R. / Feedback inhibition of insulin secretion by insulin : Relation to the hyperinsulinemia of obesity. In: New England Journal of Medicine. 1982 ; Vol. 306, No. 20. pp. 1196-1202.
@article{a9256b7b887a44b68d8db72237a02670,
title = "Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity",
abstract = "We investigated the possible existence of a negative short-loop feedback of circulating insulin on the parent beta cell in 10 lean Caucasians, 10 obese Caucasians, and 10 obese Pima Indians. Plasma insulin levels were raised acutely by 100 μU per milliliter for 90 minutes, and plasma glucose was maintained by the 'clamp' technique. C-peptide levels were 0,2166 suppressed in all groups to approximately 50 per cent of basal values. However, the obese groups had absolute C-peptide levels much higher than those of the lean group. During the hour after infusion, the rate and magnitude of C-peptide recovery in the obese groups were higher than in the lean group. Thus, negative short-loop insulin-beta-cell feedback was operative in both the lean and obese states. Despite this suppression, the insulin-secretion rate in obese subjects was still greater than that in 0,2671 non-obese subjects. Inadequate feedback suppression may account in part for the prevailing hyperinsulinemia of the obese.",
author = "D. Elahi and M. Nagulesparan and Hershcopf, {R. J.} and Muller, {D. C.} and Tobin, {J. D.} and Blix, {P. M.} and Rubenstein, {A. H.} and Unger, {Roger H} and R. Andres",
year = "1982",
language = "English (US)",
volume = "306",
pages = "1196--1202",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "20",

}

TY - JOUR

T1 - Feedback inhibition of insulin secretion by insulin

T2 - Relation to the hyperinsulinemia of obesity

AU - Elahi, D.

AU - Nagulesparan, M.

AU - Hershcopf, R. J.

AU - Muller, D. C.

AU - Tobin, J. D.

AU - Blix, P. M.

AU - Rubenstein, A. H.

AU - Unger, Roger H

AU - Andres, R.

PY - 1982

Y1 - 1982

N2 - We investigated the possible existence of a negative short-loop feedback of circulating insulin on the parent beta cell in 10 lean Caucasians, 10 obese Caucasians, and 10 obese Pima Indians. Plasma insulin levels were raised acutely by 100 μU per milliliter for 90 minutes, and plasma glucose was maintained by the 'clamp' technique. C-peptide levels were 0,2166 suppressed in all groups to approximately 50 per cent of basal values. However, the obese groups had absolute C-peptide levels much higher than those of the lean group. During the hour after infusion, the rate and magnitude of C-peptide recovery in the obese groups were higher than in the lean group. Thus, negative short-loop insulin-beta-cell feedback was operative in both the lean and obese states. Despite this suppression, the insulin-secretion rate in obese subjects was still greater than that in 0,2671 non-obese subjects. Inadequate feedback suppression may account in part for the prevailing hyperinsulinemia of the obese.

AB - We investigated the possible existence of a negative short-loop feedback of circulating insulin on the parent beta cell in 10 lean Caucasians, 10 obese Caucasians, and 10 obese Pima Indians. Plasma insulin levels were raised acutely by 100 μU per milliliter for 90 minutes, and plasma glucose was maintained by the 'clamp' technique. C-peptide levels were 0,2166 suppressed in all groups to approximately 50 per cent of basal values. However, the obese groups had absolute C-peptide levels much higher than those of the lean group. During the hour after infusion, the rate and magnitude of C-peptide recovery in the obese groups were higher than in the lean group. Thus, negative short-loop insulin-beta-cell feedback was operative in both the lean and obese states. Despite this suppression, the insulin-secretion rate in obese subjects was still greater than that in 0,2671 non-obese subjects. Inadequate feedback suppression may account in part for the prevailing hyperinsulinemia of the obese.

UR - http://www.scopus.com/inward/record.url?scp=0020048161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020048161&partnerID=8YFLogxK

M3 - Article

C2 - 7040963

AN - SCOPUS:0020048161

VL - 306

SP - 1196

EP - 1202

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 20

ER -