Feline uveal melanomas induced with feline sarcoma virus

Potential model of the human counterpart

J. A. Shadduck, D. M. Albert, J. Y. Niederkorn

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Uveal melanomas were produced by injecting Gardner strain feline fibrosarcoma virus intraocularly into 10- to 15-day-old noninbred kittens. Tumors developed in about 90% of the cats' eyes receiving virus. Progressing tumors (62 eyes of 36 cats) began as small hyperpigmented lesions at the site of injection and grew to fill the anterior chamber by 3-5 months after infection. About 30% of cats with these tumors developed secondary tumors and died. Nonprogressive tumors characterized by flat, pigmented plaques on the iris at the site of injection developed in 25 eyes of 18 cats. These lesions did not enlarge except in proportion to the growth of the eye. Tumors were composed of pigmented spindle cells, pigmented epithelioid cells, and nonpigmented spindle cells. The cells could be grown for 5-8 passages in vitro. One culture assumed a transformed morphology and grew in noninbred athymic nu/nu mice. The lesions resembled human spindle cell melanomas.

Original languageEnglish (US)
Pages (from-to)619-627
Number of pages9
JournalJournal of the National Cancer Institute
Volume67
Issue number3
StatePublished - 1981

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Feline Sarcoma Viruses
Felidae
Cats
Neoplasms
Viruses
Epithelioid Cells
Injections
Fibrosarcoma
Anterior Chamber
Iris
Uveal melanoma
Melanoma
Growth
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Feline uveal melanomas induced with feline sarcoma virus : Potential model of the human counterpart. / Shadduck, J. A.; Albert, D. M.; Niederkorn, J. Y.

In: Journal of the National Cancer Institute, Vol. 67, No. 3, 1981, p. 619-627.

Research output: Contribution to journalArticle

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