Ferritinophagy and ferroptosis in the management of metabolic diseases

Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Peter Libby, Jaakko Tuomilehto, Gregory Y.H. Lip, Josef M. Penninger, Des R. Richardson, Daolin Tang, Hao Zhou, Shuyi Wang, Daniel J. Klionsky, Guido Kroemer, Jun Ren

Research output: Contribution to journalReview articlepeer-review

Abstract

Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases, denoting the likely therapeutic promises for targeting ferroptosis in the preservation of human health. Ferritinophagy, a selective form of autophagy, contributes to the initiation of ferroptosis through degradation of ferritin, which triggers labile iron overload (IO), lipid peroxidation, membrane damage, and cell death. In this review, we will delineate the role of ferritinophagy in ferroptosis, and its underlying regulatory mechanisms, to unveil the therapeutic value of ferritinophagy as a target in the combat of ferroptosis to manage metabolic diseases.

Original languageEnglish (US)
Pages (from-to)444-462
Number of pages19
JournalTrends in Endocrinology and Metabolism
Volume32
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • ferritinophagy
  • ferroptosis
  • iron overload
  • lipid peroxidation
  • metabolic diseases

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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