Abstract
Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated molecular patterns (DAMPs) and triggered dendritic cell maturation in vitro. Furthermore, ferroptotic cells were able to vaccinate against a rechallenge with fibrosarcoma in preclinical models.
Original language | English (US) |
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Article number | 1862949 |
Journal | OncoImmunology |
Volume | 10 |
Issue number | 1 |
DOIs | |
State | Published - 2021 |
Keywords
- Damage-associated molecular pattern
- anticancer vaccination
- dendritic cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology