Ferroptosis becomes immunogenic: implications for anticancer treatments

Daolin Tang, Oliver Kepp, Guido Kroemer

Research output: Contribution to journalEditorialpeer-review

Abstract

Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated molecular patterns (DAMPs) and triggered dendritic cell maturation in vitro. Furthermore, ferroptotic cells were able to vaccinate against a rechallenge with fibrosarcoma in preclinical models.

Original languageEnglish (US)
Article number1862949
JournalOncoImmunology
Volume10
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Damage-associated molecular pattern
  • anticancer vaccination
  • dendritic cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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