Oxidative stress induced by an imbalance between oxidant and antioxidant factors is linked to various types of regulated cell death, which affects many aspects of tumor biology. Ferroptosis is a form of reactive oxygen species-dependent cell death, which is characterized by iron accumulation and lipid peroxidation. Although the direct molecular effector for ferroptosis is not known, ACSL4-and lipoxygenase-mediated production of lipid peroxides play a major role in the induction of ferroptosis. Autophagy, including ferritinophagy, lipophagy, clockophagy, and chaperone-mediated autophagy, contributes to ferroptotic cancer cell death through the upregulation of oxidative injury. In contrast, there are many antioxidant systems or proteins, such as the cystine/glutamate antiporter system xc -, GPX4, and NFE2L2, in place to limit reactive oxygen species-induced ferroptotic cancer cell death. Understanding the types of ferroptosis and their molecular machinery could open new approaches to cancer therapy.
|Original language||English (US)|
|Title of host publication||Cancer|
|Subtitle of host publication||Oxidative Stress and Dietary Antioxidants|
|Number of pages||10|
|State||Published - Jan 1 2021|
- Lipid peroxidation
ASJC Scopus subject areas