Ferroptosis in infection, inflammation, and immunity

Xin Chen, Rui Kang, Guido Kroemer, Daolin Tang

Research output: Contribution to journalReview articlepeer-review

Abstract

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. This review focuses on new discoveries related to how ferroptotic cells and their spilled contents shape innate and adaptive immunity in health and disease. Understanding the immunological characteristics and activity of ferroptotic death not only illuminates an intersection between cell death and immunity but may also lead to the development of novel treatment approaches for immunopathological diseases.

Original languageEnglish (US)
Article numbere20210518
JournalJournal of Experimental Medicine
Volume218
Issue number6
DOIs
StatePublished - May 12 2021

ASJC Scopus subject areas

  • Medicine(all)

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