Fertility-sparing surgery for ovarian low malignant potential tumors

Gautam G. Rao, Elizabeth N. Skinner, Paola A. Gehrig, Linda R. Duska, David S. Miller, John O. Schorge

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective. Ovarian low malignant potential (LMP) tumors have an excellent prognosis when treated by surgical resection. Conservative management usually involves leaving behind the uterus and contralateral adnexa to allow future childbearing. The purpose of this study was to determine the outcome of women treated with fertility-sparing surgery. Methods. All patients diagnosed with ovarian LMP tumors between 1984 and 2003 were identified at three institutions. Data were retrospectively extracted from clinical records. Results. Thirty-eight (15%) of 249 women with LMP tumors underwent fertility-sparing surgery. Twenty-three were nulliparous and four primiparous. Thirty-three (87%) underwent unilateral salpingo-ophorectomy and five (13%) cystectomy. Fourteen patients also had contralateral cystectomy or biopsy. Thirty-four (89%) were stage I, one (3%) stage II and three (8%) stage III. Most tumors had serous (55%) or mucinous (42%) histology. No patients received adjuvant therapy. Six (16%) of 38 recurred after a median follow-up of 26 months: five in the remaining ovary were salvaged with surgical resection alone, and none died from recurrent LMP tumor. Five women delivered six term infants during post-treatment surveillance. Conclusion. Fertility-sparing surgery for ovarian LMP tumors is an option for motivated patients. Preservation of the contralateral adnexa increases the risk of recurrence, but surgical resection is usually curative.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalGynecologic Oncology
Volume98
Issue number2
DOIs
StatePublished - Aug 2005

Fingerprint

Fertility
Neoplasms
Cystectomy
Adnexa Uteri
Ovary
Histology
Biopsy
Recurrence
Therapeutics

Keywords

  • Fertility-sparing surgery
  • Ovarian borderline tumor

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Rao, G. G., Skinner, E. N., Gehrig, P. A., Duska, L. R., Miller, D. S., & Schorge, J. O. (2005). Fertility-sparing surgery for ovarian low malignant potential tumors. Gynecologic Oncology, 98(2), 263-266. https://doi.org/10.1016/j.ygyno.2005.04.025

Fertility-sparing surgery for ovarian low malignant potential tumors. / Rao, Gautam G.; Skinner, Elizabeth N.; Gehrig, Paola A.; Duska, Linda R.; Miller, David S.; Schorge, John O.

In: Gynecologic Oncology, Vol. 98, No. 2, 08.2005, p. 263-266.

Research output: Contribution to journalArticle

Rao, GG, Skinner, EN, Gehrig, PA, Duska, LR, Miller, DS & Schorge, JO 2005, 'Fertility-sparing surgery for ovarian low malignant potential tumors', Gynecologic Oncology, vol. 98, no. 2, pp. 263-266. https://doi.org/10.1016/j.ygyno.2005.04.025
Rao, Gautam G. ; Skinner, Elizabeth N. ; Gehrig, Paola A. ; Duska, Linda R. ; Miller, David S. ; Schorge, John O. / Fertility-sparing surgery for ovarian low malignant potential tumors. In: Gynecologic Oncology. 2005 ; Vol. 98, No. 2. pp. 263-266.
@article{fb3f700793104bb7b34419ee607cafd1,
title = "Fertility-sparing surgery for ovarian low malignant potential tumors",
abstract = "Objective. Ovarian low malignant potential (LMP) tumors have an excellent prognosis when treated by surgical resection. Conservative management usually involves leaving behind the uterus and contralateral adnexa to allow future childbearing. The purpose of this study was to determine the outcome of women treated with fertility-sparing surgery. Methods. All patients diagnosed with ovarian LMP tumors between 1984 and 2003 were identified at three institutions. Data were retrospectively extracted from clinical records. Results. Thirty-eight (15{\%}) of 249 women with LMP tumors underwent fertility-sparing surgery. Twenty-three were nulliparous and four primiparous. Thirty-three (87{\%}) underwent unilateral salpingo-ophorectomy and five (13{\%}) cystectomy. Fourteen patients also had contralateral cystectomy or biopsy. Thirty-four (89{\%}) were stage I, one (3{\%}) stage II and three (8{\%}) stage III. Most tumors had serous (55{\%}) or mucinous (42{\%}) histology. No patients received adjuvant therapy. Six (16{\%}) of 38 recurred after a median follow-up of 26 months: five in the remaining ovary were salvaged with surgical resection alone, and none died from recurrent LMP tumor. Five women delivered six term infants during post-treatment surveillance. Conclusion. Fertility-sparing surgery for ovarian LMP tumors is an option for motivated patients. Preservation of the contralateral adnexa increases the risk of recurrence, but surgical resection is usually curative.",
keywords = "Fertility-sparing surgery, Ovarian borderline tumor",
author = "Rao, {Gautam G.} and Skinner, {Elizabeth N.} and Gehrig, {Paola A.} and Duska, {Linda R.} and Miller, {David S.} and Schorge, {John O.}",
year = "2005",
month = "8",
doi = "10.1016/j.ygyno.2005.04.025",
language = "English (US)",
volume = "98",
pages = "263--266",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Fertility-sparing surgery for ovarian low malignant potential tumors

AU - Rao, Gautam G.

AU - Skinner, Elizabeth N.

AU - Gehrig, Paola A.

AU - Duska, Linda R.

AU - Miller, David S.

AU - Schorge, John O.

PY - 2005/8

Y1 - 2005/8

N2 - Objective. Ovarian low malignant potential (LMP) tumors have an excellent prognosis when treated by surgical resection. Conservative management usually involves leaving behind the uterus and contralateral adnexa to allow future childbearing. The purpose of this study was to determine the outcome of women treated with fertility-sparing surgery. Methods. All patients diagnosed with ovarian LMP tumors between 1984 and 2003 were identified at three institutions. Data were retrospectively extracted from clinical records. Results. Thirty-eight (15%) of 249 women with LMP tumors underwent fertility-sparing surgery. Twenty-three were nulliparous and four primiparous. Thirty-three (87%) underwent unilateral salpingo-ophorectomy and five (13%) cystectomy. Fourteen patients also had contralateral cystectomy or biopsy. Thirty-four (89%) were stage I, one (3%) stage II and three (8%) stage III. Most tumors had serous (55%) or mucinous (42%) histology. No patients received adjuvant therapy. Six (16%) of 38 recurred after a median follow-up of 26 months: five in the remaining ovary were salvaged with surgical resection alone, and none died from recurrent LMP tumor. Five women delivered six term infants during post-treatment surveillance. Conclusion. Fertility-sparing surgery for ovarian LMP tumors is an option for motivated patients. Preservation of the contralateral adnexa increases the risk of recurrence, but surgical resection is usually curative.

AB - Objective. Ovarian low malignant potential (LMP) tumors have an excellent prognosis when treated by surgical resection. Conservative management usually involves leaving behind the uterus and contralateral adnexa to allow future childbearing. The purpose of this study was to determine the outcome of women treated with fertility-sparing surgery. Methods. All patients diagnosed with ovarian LMP tumors between 1984 and 2003 were identified at three institutions. Data were retrospectively extracted from clinical records. Results. Thirty-eight (15%) of 249 women with LMP tumors underwent fertility-sparing surgery. Twenty-three were nulliparous and four primiparous. Thirty-three (87%) underwent unilateral salpingo-ophorectomy and five (13%) cystectomy. Fourteen patients also had contralateral cystectomy or biopsy. Thirty-four (89%) were stage I, one (3%) stage II and three (8%) stage III. Most tumors had serous (55%) or mucinous (42%) histology. No patients received adjuvant therapy. Six (16%) of 38 recurred after a median follow-up of 26 months: five in the remaining ovary were salvaged with surgical resection alone, and none died from recurrent LMP tumor. Five women delivered six term infants during post-treatment surveillance. Conclusion. Fertility-sparing surgery for ovarian LMP tumors is an option for motivated patients. Preservation of the contralateral adnexa increases the risk of recurrence, but surgical resection is usually curative.

KW - Fertility-sparing surgery

KW - Ovarian borderline tumor

UR - http://www.scopus.com/inward/record.url?scp=22544481433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22544481433&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2005.04.025

DO - 10.1016/j.ygyno.2005.04.025

M3 - Article

C2 - 15964063

AN - SCOPUS:22544481433

VL - 98

SP - 263

EP - 266

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 2

ER -