Fetal magnetic resonance imaging in isolated diaphragmatic hernia

volume of herniated liver and neonatal outcome

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design: This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results: Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion: In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume200
Issue number3
DOIs
StatePublished - Mar 2009

Fingerprint

Diaphragmatic Hernia
Magnetic Resonance Imaging
Thorax
Liver
Lung
Pregnancy
Gestational Age
Fetus
Magnetic Resonance Spectroscopy
Retrospective Studies
Research Personnel
Congenital Diaphragmatic Hernias

Keywords

  • Congenital diaphragmatic hernia
  • magnetic resonance imaging
  • prenatal diagnosis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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title = "Fetal magnetic resonance imaging in isolated diaphragmatic hernia: volume of herniated liver and neonatal outcome",
abstract = "Objective: We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design: This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results: Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93{\%}. When the liver occupied > 20{\%} of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion: In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20{\%} of the fetal thorax was occupied by liver.",
keywords = "Congenital diaphragmatic hernia, magnetic resonance imaging, prenatal diagnosis",
author = "Worley, {Kevin C.} and Dashe, {Jodi S.} and Barber, {Robert G.} and Megison, {Stephen M.} and McIntire, {Donald D.} and Twickler, {Diane M.}",
year = "2009",
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language = "English (US)",
volume = "200",
journal = "American Journal of Obstetrics and Gynecology",
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T1 - Fetal magnetic resonance imaging in isolated diaphragmatic hernia

T2 - volume of herniated liver and neonatal outcome

AU - Worley, Kevin C.

AU - Dashe, Jodi S.

AU - Barber, Robert G.

AU - Megison, Stephen M.

AU - McIntire, Donald D.

AU - Twickler, Diane M.

PY - 2009/3

Y1 - 2009/3

N2 - Objective: We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design: This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results: Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion: In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver.

AB - Objective: We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design: This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results: Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion: In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver.

KW - Congenital diaphragmatic hernia

KW - magnetic resonance imaging

KW - prenatal diagnosis

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