Fetal syphylis: Correlation of sonographic findings and rabbit infectivity testing of amniotic fluid

L. Nathan, D. M. Twickler, M. T. Peters, P. J. Sanchez, G. D. Wendel

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Fetal syphilis is the presumed diagnosis when the sonographic findings of fetal hydrops are found in the presence of maternal syphilis. In the absence of fetal hydrops, the diagnosis of fetal infection is difficult. We hypothesized that intra-amniotic infection would be accompanied by anatomic placental and fetal abnormalities that could be detected by ultrasonography. Rabbit infectivity testing (RIT), intratesticular inoculation of rabbits with amniotic fluid, can be used to confirm intra-amniotic infection with Treponema pallidum. Twenty-one gravidas with untreated early (primary, secondary, and early latent) syphilis underwent sonography and amniocentesis for RIT at 24 weeks of gestation or later. Antenatal sonographic findings were compared to their amniotic fluid RIT results. Hepatomegaly was significantly (P < 0.01) associated with amniotic fluid infection detected by RIT. Antenatal detection of hepatomegaly, which is probably the initial sonographic manifestation of hydrops fetalis, may ultimately identify the fetus affected with congenital syphilis.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalJournal of Ultrasound in Medicine
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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