Fetus in fetu: Molecular analysis of a fetiform mass

A. Hing, J. Corteville, R. P. Foglia, D. P. Bliss, H. Donis-Keller, S. B. Dowton

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Fetus-in-fetu is a rare condition presenting as a calcified intra- abdominal mass in the newborn infant. Over 50 cases of fetus-in-fetu have been reported since 1800. Karyotype analysis in 8 cases and protein polymorphisms in 4 documented identical findings in the host and fetiform mass. We report a case of fetus-in-fetu in a newborn female including cytogenetic and molecular studies of both the host and mass. Genotypic information from 7 polymerase chain reaction (PCR) assays representing 4 chromosomes demonstrates heterozygous and identical alleles in the infant and fetus-in-fetu at all loci studied. A review of the literature is provided including a discussion regarding the impact of molecular data on present hypotheses of fetus-in-fetu pathogenesis.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalAmerican Journal of Medical Genetics
Volume47
Issue number3
StatePublished - 1993

Fingerprint

Fetus
Newborn Infant
Chromosomes, Human, Pair 4
Karyotype
Cytogenetics
Alleles
Polymerase Chain Reaction
Proteins

Keywords

  • intra-abdominal mass
  • teratoma
  • twin

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Hing, A., Corteville, J., Foglia, R. P., Bliss, D. P., Donis-Keller, H., & Dowton, S. B. (1993). Fetus in fetu: Molecular analysis of a fetiform mass. American Journal of Medical Genetics, 47(3), 333-341.

Fetus in fetu : Molecular analysis of a fetiform mass. / Hing, A.; Corteville, J.; Foglia, R. P.; Bliss, D. P.; Donis-Keller, H.; Dowton, S. B.

In: American Journal of Medical Genetics, Vol. 47, No. 3, 1993, p. 333-341.

Research output: Contribution to journalArticle

Hing, A, Corteville, J, Foglia, RP, Bliss, DP, Donis-Keller, H & Dowton, SB 1993, 'Fetus in fetu: Molecular analysis of a fetiform mass', American Journal of Medical Genetics, vol. 47, no. 3, pp. 333-341.
Hing A, Corteville J, Foglia RP, Bliss DP, Donis-Keller H, Dowton SB. Fetus in fetu: Molecular analysis of a fetiform mass. American Journal of Medical Genetics. 1993;47(3):333-341.
Hing, A. ; Corteville, J. ; Foglia, R. P. ; Bliss, D. P. ; Donis-Keller, H. ; Dowton, S. B. / Fetus in fetu : Molecular analysis of a fetiform mass. In: American Journal of Medical Genetics. 1993 ; Vol. 47, No. 3. pp. 333-341.
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