Fever control and its impact on outcomes: What is the evidence?

Venkatesh Aiyagari, Michael N. Diringer

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Fever is common in a variety of neurological disorders. There is abundant experimental evidence suggesting that fever leads to, or exacerbates, neuronal injury in conditions such as cerebral ischemia and traumatic brain injury. However, conclusive evidence linking control of fever to improved outcomes is lacking. It has been difficult to design studies looking at the impact of fever control on outcome, in part because traditional methods of fever control are ineffective. Recently, several new devices to control temperature have become available. These devices appear to be more effective than conventional means and might allow us to design studies that definitively answer the question: "Does controlling fever improve outcome?".

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalJournal of the Neurological Sciences
Volume261
Issue number1-2
DOIs
StatePublished - Oct 15 2007

Fingerprint

Fever
Equipment and Supplies
Nervous System Diseases
Brain Ischemia
Temperature
Wounds and Injuries

Keywords

  • Cerebrovascular accident
  • Fever
  • Intensive care
  • Non-narcotic analgesics
  • Traumatic brain injury

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Fever control and its impact on outcomes : What is the evidence? / Aiyagari, Venkatesh; Diringer, Michael N.

In: Journal of the Neurological Sciences, Vol. 261, No. 1-2, 15.10.2007, p. 39-46.

Research output: Contribution to journalArticle

@article{5fcbc3f424824e13b971b75331b9b761,
title = "Fever control and its impact on outcomes: What is the evidence?",
abstract = "Fever is common in a variety of neurological disorders. There is abundant experimental evidence suggesting that fever leads to, or exacerbates, neuronal injury in conditions such as cerebral ischemia and traumatic brain injury. However, conclusive evidence linking control of fever to improved outcomes is lacking. It has been difficult to design studies looking at the impact of fever control on outcome, in part because traditional methods of fever control are ineffective. Recently, several new devices to control temperature have become available. These devices appear to be more effective than conventional means and might allow us to design studies that definitively answer the question: {"}Does controlling fever improve outcome?{"}.",
keywords = "Cerebrovascular accident, Fever, Intensive care, Non-narcotic analgesics, Traumatic brain injury",
author = "Venkatesh Aiyagari and Diringer, {Michael N.}",
year = "2007",
month = "10",
day = "15",
doi = "10.1016/j.jns.2007.04.030",
language = "English (US)",
volume = "261",
pages = "39--46",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Fever control and its impact on outcomes

T2 - What is the evidence?

AU - Aiyagari, Venkatesh

AU - Diringer, Michael N.

PY - 2007/10/15

Y1 - 2007/10/15

N2 - Fever is common in a variety of neurological disorders. There is abundant experimental evidence suggesting that fever leads to, or exacerbates, neuronal injury in conditions such as cerebral ischemia and traumatic brain injury. However, conclusive evidence linking control of fever to improved outcomes is lacking. It has been difficult to design studies looking at the impact of fever control on outcome, in part because traditional methods of fever control are ineffective. Recently, several new devices to control temperature have become available. These devices appear to be more effective than conventional means and might allow us to design studies that definitively answer the question: "Does controlling fever improve outcome?".

AB - Fever is common in a variety of neurological disorders. There is abundant experimental evidence suggesting that fever leads to, or exacerbates, neuronal injury in conditions such as cerebral ischemia and traumatic brain injury. However, conclusive evidence linking control of fever to improved outcomes is lacking. It has been difficult to design studies looking at the impact of fever control on outcome, in part because traditional methods of fever control are ineffective. Recently, several new devices to control temperature have become available. These devices appear to be more effective than conventional means and might allow us to design studies that definitively answer the question: "Does controlling fever improve outcome?".

KW - Cerebrovascular accident

KW - Fever

KW - Intensive care

KW - Non-narcotic analgesics

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=34548145987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548145987&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2007.04.030

DO - 10.1016/j.jns.2007.04.030

M3 - Article

C2 - 17537459

AN - SCOPUS:34548145987

VL - 261

SP - 39

EP - 46

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -