@article{55948c2ca7bb44e787ac5927ea48b53a,
title = "FGF21 regulates sweet and alcohol preference",
abstract = "Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.",
author = "Saswata Talukdar and Owen, {Bryn M.} and Parkyong Song and Genaro Hernandez and Yuan Zhang and Yingjiang Zhou and Scott, {William T.} and Bhavna Paratala and Tod Turner and Andrew Smith and Barbara Bernardo and M{\"u}ller, {Christian P.} and Hao Tang and Mangelsdorf, {David J.} and Bryan Goodwin and Kliewer, {Steven A.}",
note = "Funding Information: We thank Birgitte Andersen (Novo Nordisk) for providing recombinant FGF21, Yang Xie for assistance with the statistical analyses, and David Self for assistance with brain dissection. This work was supported by National Institutes of Health grants R01DK067158 (S.A.K. and D.J.M.), R01CA152301 (H.T.), NNX11AC54G (H.T.), and 5P50 CA70907-16 (H.T.); the Robert A. Welch Foundation (grant I-1558 to S.A.K. and grant I-1275 to D.J.M.); the Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 105545/Z/14/Z to B.M.O.); the Ford Foundation Fellowship (G.H.); the German National Science Foundation (DFG) grant MU 2789/8-1 and IZKF (Project E13) (C.P.M.); and the Howard Hughes Medical Institute (D.J.M.). Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = feb,
day = "9",
doi = "10.1016/j.cmet.2015.12.008",
language = "English (US)",
volume = "23",
pages = "344--349",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",
}