fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation

T. P. Yamaguchi, K. Harpal, M. Henkemeyer, J. Rossant

Research output: Contribution to journalArticle

596 Scopus citations

Abstract

Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development. In the absence of fgfr-1 signaling, embryos displayed early growth defects; however, they remained capable of gastrulating and generating mesoderm. The nascent mesoderm of fgfr-1 homozygous mutant embryos differentiated into diverse mesodermal subtypes, but mesodermal patterning was aberrant. Somites were never generated and axial mesoderm was greatly expanded at the expense of paraxial mesoderm. These results suggest that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation.

Original languageEnglish (US)
Pages (from-to)3032-3044
Number of pages13
JournalGenes and Development
Volume8
Issue number24
DOIs
StatePublished - Dec 15 1994

Keywords

  • Mesoderm induction
  • gene targeting
  • notochord
  • primitive streak
  • somites

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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