Abstract
ABSTRACT: Herein we present 2 mCRPC (metastatic castration-resistant prostate cancer) patients who underwent 68Ga-PSMA PET/CT for PSMA-targeted radioligand therapy eligibility. Prior studies have noted aggressive clinical behavior and poor prognosis associated with discordant FDG positivity and low PSMA expression. Accordingly, the patients also underwent 18F-FDG PET/CT, which revealed intratumoral heterogeneity. Therefore, an additional PET/CT targeting fibroblast activation proteins (FAPs) using 68Ga-FAPI-04 was performed to assess the potential for an FAP-targeted therapy. This report highlights the theranostic potential of FAP imaging in mCRPC, particularly in patients with heterogeneous tumor phenotypes.
Original language | English (US) |
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Pages (from-to) | e54-e55 |
Journal | Clinical nuclear medicine |
Volume | 47 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2022 |
Externally published | Yes |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging