Fibroblast growth factor 2 control of vascular tone

Ming Zhou, Roy L. Sutliff, Richard J. Paul, John N. Lorenz, James B. Hoying, Christian C. Haudenschild, Moving Yin, J. Douglas Coffin, Ling Kong, Evangelia G. Kranias, Wusheng Luo, Gregory P. Boivin, John J. Duffy, Sharon A. Pawlowski, Thomas Doetschman

Research output: Contribution to journalArticle

274 Citations (Scopus)

Abstract

Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature regulation, digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers of vessel walls, functions in vascular tone control. Fgf2 knockout mice are morphologically normal and display decreased vascular smooth muscle contractility, low blood pressure and thrombocytosuis. Following intra- arterial mechanical injury, FGF2-deficient vessels undergo a normal hyperplastic response. These results force us to reconsider the function of FGF2 in vascular development and homeostasis in terms of vascular tone control.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalNature Medicine
Volume4
Issue number2
DOIs
StatePublished - Apr 7 1998

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Fibroblast Growth Factor 2
Blood Vessels
Blood pressure
Pressure regulation
Wall function
Physiology
Metabolism
Muscle
Intercellular Signaling Peptides and Proteins
Wounds and Injuries
Repair
Display devices
Vascular Smooth Muscle
Knockout Mice
Wound Healing
Hypotension
Tissue
Reperfusion
Digestion
Shock

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zhou, M., Sutliff, R. L., Paul, R. J., Lorenz, J. N., Hoying, J. B., Haudenschild, C. C., ... Doetschman, T. (1998). Fibroblast growth factor 2 control of vascular tone. Nature Medicine, 4(2), 201-207. https://doi.org/10.1038/nm0298-201

Fibroblast growth factor 2 control of vascular tone. / Zhou, Ming; Sutliff, Roy L.; Paul, Richard J.; Lorenz, John N.; Hoying, James B.; Haudenschild, Christian C.; Yin, Moving; Coffin, J. Douglas; Kong, Ling; Kranias, Evangelia G.; Luo, Wusheng; Boivin, Gregory P.; Duffy, John J.; Pawlowski, Sharon A.; Doetschman, Thomas.

In: Nature Medicine, Vol. 4, No. 2, 07.04.1998, p. 201-207.

Research output: Contribution to journalArticle

Zhou, M, Sutliff, RL, Paul, RJ, Lorenz, JN, Hoying, JB, Haudenschild, CC, Yin, M, Coffin, JD, Kong, L, Kranias, EG, Luo, W, Boivin, GP, Duffy, JJ, Pawlowski, SA & Doetschman, T 1998, 'Fibroblast growth factor 2 control of vascular tone', Nature Medicine, vol. 4, no. 2, pp. 201-207. https://doi.org/10.1038/nm0298-201
Zhou M, Sutliff RL, Paul RJ, Lorenz JN, Hoying JB, Haudenschild CC et al. Fibroblast growth factor 2 control of vascular tone. Nature Medicine. 1998 Apr 7;4(2):201-207. https://doi.org/10.1038/nm0298-201
Zhou, Ming ; Sutliff, Roy L. ; Paul, Richard J. ; Lorenz, John N. ; Hoying, James B. ; Haudenschild, Christian C. ; Yin, Moving ; Coffin, J. Douglas ; Kong, Ling ; Kranias, Evangelia G. ; Luo, Wusheng ; Boivin, Gregory P. ; Duffy, John J. ; Pawlowski, Sharon A. ; Doetschman, Thomas. / Fibroblast growth factor 2 control of vascular tone. In: Nature Medicine. 1998 ; Vol. 4, No. 2. pp. 201-207.
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