Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells

Julia Yu Fong Chang, Cong Wang, Junchen Liu, Yanqing Huang, Chengliu Jin, Chaofeng Yang, Bo Hai, Fei Liu, Rena N. D'Souza, Wallace L. McKeehan, Fen Wang

Research output: Contribution to journalArticle

14 Scopus citations


Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.

Original languageEnglish (US)
Pages (from-to)28952-28961
Number of pages10
JournalJournal of Biological Chemistry
Issue number40
Publication statusPublished - Oct 4 2013


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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