Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells

Julia Yu Fong Chang, Cong Wang, Junchen Liu, Yanqing Huang, Chengliu Jin, Chaofeng Yang, Bo Hai, Fei Liu, Rena N. D'Souza, Wallace L. McKeehan, Fen Wang

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.

Original languageEnglish (US)
Pages (from-to)28952-28961
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Chang, J. Y. F., Wang, C., Liu, J., Huang, Y., Jin, C., Yang, C., Hai, B., Liu, F., D'Souza, R. N., McKeehan, W. L., & Wang, F. (2013). Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells. Journal of Biological Chemistry, 288(40), 28952-28961. https://doi.org/10.1074/jbc.M113.506873