Fibroblast mechanics in three-dimensional collagen matrices

Frederick Grinnell

doi:10.1016/j.jbmt.2008.03.005

Fibroblast mechanics in three-dimensional collagen matrices

Frederick Grinnell

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.

Original language	English (US)
Pages (from-to)	191-193
Number of pages	3
Journal	Journal of Bodywork and Movement Therapies
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.jbmt.2008.03.005
State	Published - Jul 2008

Keywords

Contraction
Fascia
Growth factor
Migration
Regulation
Tension

ASJC Scopus subject areas

Complementary and Manual Therapy
Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation
Complementary and alternative medicine

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10.1016/j.jbmt.2008.03.005

Cite this

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title = "Fibroblast mechanics in three-dimensional collagen matrices",

abstract = "Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.",

keywords = "Contraction, Fascia, Growth factor, Migration, Regulation, Tension",

author = "Frederick Grinnell",

note = "Funding Information: The author's research is supported by a grant from the National Institutes of Health, GM31321. ",

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AU - Grinnell, Frederick

N1 - Funding Information: The author's research is supported by a grant from the National Institutes of Health, GM31321.

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N2 - Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.

AB - Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.

KW - Contraction

KW - Fascia

KW - Growth factor

KW - Migration

KW - Regulation

KW - Tension

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ER -

Fibroblast mechanics in three-dimensional collagen matrices

Abstract

Keywords

ASJC Scopus subject areas

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