Fibrosis and adipose tissue dysfunction

Kai Sun, Joan Tordjman, Karine Clément, Philipp E. Scherer

Research output: Contribution to journalReview articlepeer-review

370 Scopus citations

Abstract

Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1a that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an equally important role on systemic metabolic alterations as fibrotic conditions play in the liver, heart, and kidney. Here, we discuss recent advances in our understanding of the genesis, modulation, and systemic impact of excessive extracellular matrix (ECM) accumulation in adipose tissue of both rodents and humans and the ensuing impact on metabolic dysfunction.

Original languageEnglish (US)
Pages (from-to)470-477
Number of pages8
JournalCell Metabolism
Volume18
Issue number4
DOIs
StatePublished - Oct 1 2013

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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