Fifty years of advances in bile acid synthesis and metabolism

Research output: Contribution to journalReview article

184 Scopus citations

Abstract

There are two major pathways that mammalian cells use to supply themselves with cholesterol, one involving the synthesis of sterols from acetyl-CoA and the other the metabolism of cholesterol-rich lipoprotein particles via receptor-mediated endocytosis. There also are several pathways that mammalian cells use to break down cholesterol, and these disposal pathways are equal in physiological importance to the supply pathways. A major catabolic route involves conversion of cholesterol into conjugated bile salts, a transformation mediated by 16 or more liver enzymes. This review highlights findings in cholesterol catabolism from the last five decades with special emphasis on advances in bile acid synthesis, transport, and regulation.

Original languageEnglish (US)
Pages (from-to)S120-S125
JournalJournal of lipid research
Volume50
Issue numberSUPPL.
DOIs
StatePublished - Apr 1 2009

Keywords

  • Catabolism
  • Cholesterol
  • Liver
  • Nuclear receptors
  • Transporters

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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