Fifty years of advances in bile acid synthesis and metabolism

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

There are two major pathways that mammalian cells use to supply themselves with cholesterol, one involving the synthesis of sterols from acetyl-CoA and the other the metabolism of cholesterol-rich lipoprotein particles via receptor-mediated endocytosis. There also are several pathways that mammalian cells use to break down cholesterol, and these disposal pathways are equal in physiological importance to the supply pathways. A major catabolic route involves conversion of cholesterol into conjugated bile salts, a transformation mediated by 16 or more liver enzymes. This review highlights findings in cholesterol catabolism from the last five decades with special emphasis on advances in bile acid synthesis, transport, and regulation.

Original languageEnglish (US)
JournalJournal of Lipid Research
Volume50
Issue numberSUPPL.
DOIs
StatePublished - Apr 2009

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Bile Acids and Salts
Metabolism
Cholesterol
Acetyl Coenzyme A
Cells
Sterols
Endocytosis
Liver
Lipoproteins
Enzymes

Keywords

  • Catabolism
  • Cholesterol
  • Liver
  • Nuclear receptors
  • Transporters

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

Fifty years of advances in bile acid synthesis and metabolism. / Russell, David W.

In: Journal of Lipid Research, Vol. 50, No. SUPPL., 04.2009.

Research output: Contribution to journalArticle

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