Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs

Mehmet Fatih Cansizoglu, Erdal Toprak

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Antibiotic resistance is a worldwide public health problem (Bush et al. in Nat Rev Microbiol 9:894–896, 2011). The lack of effective therapies against resistant bacteria globally leads to prolonged treatments, increased mortality, and inflating health care costs (Oz et al. in Mol Biol Evol 31:2387–2401, 2014; Martinez in Science 321:365–367, 2008; Lipsitch et al. in Proc Natl Acad Sci USA 97:1938–1943, 2000; Taubes in Science 321:356–361, 2008; Laxminarayan et al. in Lancet, 2016; Laxminarayan et al. in Lancet Infect Dis 13:1057–1098, 2013). Current efforts towards a solution of this problem can be boiled down to two main strategies: (1) developing of new antimicrobial agents and (2) searching for smart strategies that can restore or preserve the efficacy of existing antimicrobial agents. In this short review article, we discuss the need for evolvable antimicrobial agents, focusing on a new antimicrobial technology that utilizes peptide-conjugated phosphorodiamidate morpholino oligomers to inhibit the growth of pathogenic bacteria by targeting bacterial genes.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalCurrent Genetics
DOIs
StateAccepted/In press - May 11 2017

Keywords

  • Antibiotic resistance
  • Evolution
  • Gene silencing
  • Microbial evolution
  • Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs)

ASJC Scopus subject areas

  • Genetics

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