Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs

Mehmet Fatih Cansizoglu, Erdal Toprak

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Antibiotic resistance is a worldwide public health problem (Bush et al. in Nat Rev Microbiol 9:894–896, 2011). The lack of effective therapies against resistant bacteria globally leads to prolonged treatments, increased mortality, and inflating health care costs (Oz et al. in Mol Biol Evol 31:2387–2401, 2014; Martinez in Science 321:365–367, 2008; Lipsitch et al. in Proc Natl Acad Sci USA 97:1938–1943, 2000; Taubes in Science 321:356–361, 2008; Laxminarayan et al. in Lancet, 2016; Laxminarayan et al. in Lancet Infect Dis 13:1057–1098, 2013). Current efforts towards a solution of this problem can be boiled down to two main strategies: (1) developing of new antimicrobial agents and (2) searching for smart strategies that can restore or preserve the efficacy of existing antimicrobial agents. In this short review article, we discuss the need for evolvable antimicrobial agents, focusing on a new antimicrobial technology that utilizes peptide-conjugated phosphorodiamidate morpholino oligomers to inhibit the growth of pathogenic bacteria by targeting bacterial genes.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalCurrent Genetics
DOIs
StateAccepted/In press - May 11 2017

Fingerprint

Microbial Drug Resistance
Anti-Infective Agents
Pharmaceutical Preparations
Bacteria
Bacterial Genes
Morpholinos
Health Care Costs
Public Health
Technology
Peptides
Mortality
Growth
Therapeutics

Keywords

  • Antibiotic resistance
  • Evolution
  • Gene silencing
  • Microbial evolution
  • Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs)

ASJC Scopus subject areas

  • Genetics

Cite this

Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs. / Cansizoglu, Mehmet Fatih; Toprak, Erdal.

In: Current Genetics, 11.05.2017, p. 1-4.

Research output: Contribution to journalArticle

@article{e625fd01be114f8a8a0bf92b50c918b4,
title = "Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs",
abstract = "Antibiotic resistance is a worldwide public health problem (Bush et al. in Nat Rev Microbiol 9:894–896, 2011). The lack of effective therapies against resistant bacteria globally leads to prolonged treatments, increased mortality, and inflating health care costs (Oz et al. in Mol Biol Evol 31:2387–2401, 2014; Martinez in Science 321:365–367, 2008; Lipsitch et al. in Proc Natl Acad Sci USA 97:1938–1943, 2000; Taubes in Science 321:356–361, 2008; Laxminarayan et al. in Lancet, 2016; Laxminarayan et al. in Lancet Infect Dis 13:1057–1098, 2013). Current efforts towards a solution of this problem can be boiled down to two main strategies: (1) developing of new antimicrobial agents and (2) searching for smart strategies that can restore or preserve the efficacy of existing antimicrobial agents. In this short review article, we discuss the need for evolvable antimicrobial agents, focusing on a new antimicrobial technology that utilizes peptide-conjugated phosphorodiamidate morpholino oligomers to inhibit the growth of pathogenic bacteria by targeting bacterial genes.",
keywords = "Antibiotic resistance, Evolution, Gene silencing, Microbial evolution, Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs)",
author = "Cansizoglu, {Mehmet Fatih} and Erdal Toprak",
year = "2017",
month = "5",
day = "11",
doi = "10.1007/s00294-017-0703-x",
language = "English (US)",
pages = "1--4",
journal = "Current Genetics",
issn = "0172-8083",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs

AU - Cansizoglu, Mehmet Fatih

AU - Toprak, Erdal

PY - 2017/5/11

Y1 - 2017/5/11

N2 - Antibiotic resistance is a worldwide public health problem (Bush et al. in Nat Rev Microbiol 9:894–896, 2011). The lack of effective therapies against resistant bacteria globally leads to prolonged treatments, increased mortality, and inflating health care costs (Oz et al. in Mol Biol Evol 31:2387–2401, 2014; Martinez in Science 321:365–367, 2008; Lipsitch et al. in Proc Natl Acad Sci USA 97:1938–1943, 2000; Taubes in Science 321:356–361, 2008; Laxminarayan et al. in Lancet, 2016; Laxminarayan et al. in Lancet Infect Dis 13:1057–1098, 2013). Current efforts towards a solution of this problem can be boiled down to two main strategies: (1) developing of new antimicrobial agents and (2) searching for smart strategies that can restore or preserve the efficacy of existing antimicrobial agents. In this short review article, we discuss the need for evolvable antimicrobial agents, focusing on a new antimicrobial technology that utilizes peptide-conjugated phosphorodiamidate morpholino oligomers to inhibit the growth of pathogenic bacteria by targeting bacterial genes.

AB - Antibiotic resistance is a worldwide public health problem (Bush et al. in Nat Rev Microbiol 9:894–896, 2011). The lack of effective therapies against resistant bacteria globally leads to prolonged treatments, increased mortality, and inflating health care costs (Oz et al. in Mol Biol Evol 31:2387–2401, 2014; Martinez in Science 321:365–367, 2008; Lipsitch et al. in Proc Natl Acad Sci USA 97:1938–1943, 2000; Taubes in Science 321:356–361, 2008; Laxminarayan et al. in Lancet, 2016; Laxminarayan et al. in Lancet Infect Dis 13:1057–1098, 2013). Current efforts towards a solution of this problem can be boiled down to two main strategies: (1) developing of new antimicrobial agents and (2) searching for smart strategies that can restore or preserve the efficacy of existing antimicrobial agents. In this short review article, we discuss the need for evolvable antimicrobial agents, focusing on a new antimicrobial technology that utilizes peptide-conjugated phosphorodiamidate morpholino oligomers to inhibit the growth of pathogenic bacteria by targeting bacterial genes.

KW - Antibiotic resistance

KW - Evolution

KW - Gene silencing

KW - Microbial evolution

KW - Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs)

UR - http://www.scopus.com/inward/record.url?scp=85018664557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018664557&partnerID=8YFLogxK

U2 - 10.1007/s00294-017-0703-x

DO - 10.1007/s00294-017-0703-x

M3 - Article

C2 - 28497241

AN - SCOPUS:85018664557

SP - 1

EP - 4

JO - Current Genetics

JF - Current Genetics

SN - 0172-8083

ER -