Fighting Fat with Fat

The Expanding Field of Adipose Stem Cells

Daniel Zeve, Wei Tang, Jon Graff

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

We are in the midst of a dire, unprecedented, and global epidemic of obesity and secondary sequelae, most prominently diabetes and hyperlipidemia. Underlying this epidemic is the most hated of cells, adipocytes, and their inherent dynamic ability to expand and renew. This capacity highlights a heretofore undefined stem compartment. Recent in vivo studies, relying upon lineage tracing and flow cytometry methods, have begun to unravel the identity of adipose stem cells, their niche, and the dynamism central to adipose expansion. Thus, the field is moving in a direction that may allow us to manipulate adipose stem cells to beneficial therapeutic ends.

Original languageEnglish (US)
Pages (from-to)472-481
Number of pages10
JournalCell Stem Cell
Volume5
Issue number5
DOIs
StatePublished - Nov 6 2009

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Stem Cells
Fats
Stem Cell Niche
Hyperlipidemias
Adipocytes
Flow Cytometry
Obesity
Therapeutics
Direction compound

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

Cite this

Fighting Fat with Fat : The Expanding Field of Adipose Stem Cells. / Zeve, Daniel; Tang, Wei; Graff, Jon.

In: Cell Stem Cell, Vol. 5, No. 5, 06.11.2009, p. 472-481.

Research output: Contribution to journalArticle

Zeve, Daniel ; Tang, Wei ; Graff, Jon. / Fighting Fat with Fat : The Expanding Field of Adipose Stem Cells. In: Cell Stem Cell. 2009 ; Vol. 5, No. 5. pp. 472-481.
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