Fighting Fat with Fat: The Expanding Field of Adipose Stem Cells

Daniel Zeve, Wei Tang, Jon Graff

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

We are in the midst of a dire, unprecedented, and global epidemic of obesity and secondary sequelae, most prominently diabetes and hyperlipidemia. Underlying this epidemic is the most hated of cells, adipocytes, and their inherent dynamic ability to expand and renew. This capacity highlights a heretofore undefined stem compartment. Recent in vivo studies, relying upon lineage tracing and flow cytometry methods, have begun to unravel the identity of adipose stem cells, their niche, and the dynamism central to adipose expansion. Thus, the field is moving in a direction that may allow us to manipulate adipose stem cells to beneficial therapeutic ends.

Original languageEnglish (US)
Pages (from-to)472-481
Number of pages10
JournalCell Stem Cell
Volume5
Issue number5
DOIs
Publication statusPublished - Nov 6 2009

    Fingerprint

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

Cite this