TY - JOUR
T1 - Fighting Fat with Fat
T2 - The Expanding Field of Adipose Stem Cells
AU - Zeve, Daniel
AU - Tang, Wei
AU - Graff, Jon
PY - 2009/11/6
Y1 - 2009/11/6
N2 - We are in the midst of a dire, unprecedented, and global epidemic of obesity and secondary sequelae, most prominently diabetes and hyperlipidemia. Underlying this epidemic is the most hated of cells, adipocytes, and their inherent dynamic ability to expand and renew. This capacity highlights a heretofore undefined stem compartment. Recent in vivo studies, relying upon lineage tracing and flow cytometry methods, have begun to unravel the identity of adipose stem cells, their niche, and the dynamism central to adipose expansion. Thus, the field is moving in a direction that may allow us to manipulate adipose stem cells to beneficial therapeutic ends.
AB - We are in the midst of a dire, unprecedented, and global epidemic of obesity and secondary sequelae, most prominently diabetes and hyperlipidemia. Underlying this epidemic is the most hated of cells, adipocytes, and their inherent dynamic ability to expand and renew. This capacity highlights a heretofore undefined stem compartment. Recent in vivo studies, relying upon lineage tracing and flow cytometry methods, have begun to unravel the identity of adipose stem cells, their niche, and the dynamism central to adipose expansion. Thus, the field is moving in a direction that may allow us to manipulate adipose stem cells to beneficial therapeutic ends.
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U2 - 10.1016/j.stem.2009.10.014
DO - 10.1016/j.stem.2009.10.014
M3 - Review article
C2 - 19896439
AN - SCOPUS:70350515669
SN - 1934-5909
VL - 5
SP - 472
EP - 481
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 5
ER -